Gallbladder carcinoma: a retrospective analysis of twenty-two years experience of a single teaching hospital
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Gallbladder carcinoma: a retrospective analysis of twenty-two years experience of a single teaching hospital Muhammed Ashraf Memon*1,2, Suhail Anwar3, M Hanif Shiwani3 and Breda Memon4 Address: 1Department of Surgery, Creighton University, Omaha, Nebraska, USA, 2Department of Surgery, Whiston Hospital, Prescot, Merseyside, L35 5DR, UK, 3Department of Surgery, Barnsley District General Hospital, Barnsley, South Yorkshire, S75 2EP, UK and 4Private Clinic, Astley House, Whitehall Road, Darwen, Lancashire, BB3 2LH, UK Email: Muhammed Ashraf Memon* - [email protected]; Suhail Anwar - [email protected]; M Hanif Shiwani - [email protected]; Breda Memon - [email protected] * Corresponding author
Published: 17 March 2005 International Seminars in Surgical Oncology 2005, 2:6
doi:10.1186/1477-7800-2-6
Received: 05 January 2005 Accepted: 17 March 2005
This article is available from: http://www.issoonline.com/content/2/1/6 © 2005 Memon et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
CarcinomaGallbladderHuman
Abstract Background: The purpose of this study was to retrospectively evaluate our experience with gallbladder cancer since the establishment of a tumour registry in our institute. Methods: Between 1975 and 1998, 23 consecutive patients with gallbladder cancer were identified using the tumour registry database. There were 18 females (78%) and 5 (22%) males. The mean age at diagnosis was 70.6 (range 42–85) years. The diagnosis was achieved either intra-operatively or following the histological analysis of the gallbladder (n = 17), following gallbladder or liver biopsy (n = 4) or at autopsy (n = 2). Presenting symptoms included upper abdominal pain, weight loss, nausea, vomiting, fever, painless jaundice, hepatomegaly, upper abdominal mass, upper abdominal tenderness, and gastrointestinal haemorrhage. Results: Histological examination revealed 20 adenocarcinomas (87%), 2 squamous cell carcinomas (9%) and one spindle cell sarcoma (4%). At presentation, 14 (61%) gallbladder cancers were stage IV, 5 (22%) were stage III and 4 (17%) were stage II. Kaplan Meier analysis revealed a mean survival of 3.2, 7.8 and 8.2 months for stage IV, III, and II disease respectively. Out of 14 patients with stage IV disease, 8 patients received adjuvant chemotherapy and survived for 4.6 months whereas six patients who did not receive adjuvant chemotherapy survived for 1.3 months. This difference was statistically significant (p = 0.04). Conclusion: The majority of patients with gallbladder cancer presented with advanced stage disease (stage IV) which carries a dismal prognosis. Patients who received chemotherapy with stage IV disease, however, did better than those who did not, but this is probably a reflection of patient selection.
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