Gemcitabine
- PDF / 141,237 Bytes
- 1 Pages / 623.591 x 841.847 pts Page_size
- 53 Downloads / 165 Views
1
S
Interstitial nephritis leading to renal failure: 2 case reports Two men developed tubulointerstitial nephritis while receiving gemcitabine for advanced pancreatic cancer. They subsequently died from renal failure. A 50-year-old man started receiving IV gemcitabine 1000 mg/m2 in 30 minutes once weekly for 2 weeks in a 3-weekly cycle. He was well until, after 23 months, his serum urea nitrogen level suddenly increased to 87 mg/dL and his serum creatinine level increased to 4.4 mg/dL. He died from renal failure. A 67-year-old man received a modified gemcitabine regimen [dosage not stated]. He was well until, after 11 months, he had sudden increases in his serum urea nitrogen and serum creatinine levels. He died from renal failure. Histological analysis from autopsy revealed acute tubulointerstitial nephritis in the kidneys of both patients. There was interstitial oedema and lymphocytic infiltration of plasma cells and some granulocytes. Tubules had cystic dilatation and attenuated epithelium. Focally, the inflammatory cells had infiltrated the tubules with partial epithelial destruction. Within the lumen, crystal deposits were frequently observed. Yamamoto A, et al. Acute tubulointerstitial nephritis associated with long-term 801090606 gemcitabine therapy. Pancreas 34: 378-379, No. 3, Apr 2007 - Japan
0114-9954/10/1162-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 28 Jul 2007 No. 1162
Data Loading...
