Gemcitabine
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Gemcitabine Pseudocellulitis: case report A 77-year-old woman developed pseudocellulitis while receiving adjuvant chemotherapy with gemcitabine for pancreatic adenocarcinoma. The woman with a history of peripheral vascular disease, dyslipidemia, hypertension, pancreatitis, bilateral carotid stenosis, diverticulitis, gastroesophageal reflux disease and pancreatic adenocarcinoma, started receiving adjuvant gemcitabine therapy at 65% of the ideal dose [exact dosage and route not stated]. Eleven days after the initiation of gemcitabine treatment, she presented to emergency department with a fever and erythema, swelling, and tenderness in her lower legs. Under a suspicion of potential gemcitabine-induced pseudocellulitis her chemotherapy was held on. Subsequently, she received a course of antibiotics and referred for further assessment. Her lower limb ultrasonography showed a right great saphenous vein thrombosis with no deep venous thrombosis. Her dalteparin, which was initiated in emergency department was discontinued. One week later she had ongoing complaints of left leg swelling and moderate-to-severe pain over the lower third and medial aspect of her leg. She received amoxicillin–clavulanic acid presuming her condition as cellulitis. She had a pain described as burning with a severity of 6 out of 10. Examinations revealed her vital signs as stable, and both lower limbs appeared dusky and swollen. At that point she was diagnosed with pseudocellulitis secondary to gemcitabine therapy. The treatment with gemcitabine was discontinued permanently and she received cefalexin. It was concluded that the her venous stasis and chronic insufficiency likely contributed to a gemcitabine-induced pseudocellulitis. At a 3 months follow-up, her symptoms had resolved and her legs showed only signs of venous insufficiency. Author comment: "A thorough workup was completed, and the patient was eventually diagnosed with gemcitabine induced pseudocellulitis." Bami H, et al. Gemcitabine-induced pseudocellulitis: A case report and review of the literature. Current Oncology 26: e703-e706, No. 5, Jan 2019. Available from: 803437897 URL: http://doi.org/10.3747/co.26.5007 - Canada
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Reactions 7 Dec 2019 No. 1782
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