Gender-specific siblings and women with maternal history of diabetes are at high risk of developing type2 diabetes-a fam
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ORIGINAL ARTICLE
Gender-specific siblings and women with maternal history of diabetes are at high risk of developing type2 diabetes-a family study from South India Rizwana Parveen 1 & Satyavani Kumpatla 2 & Shalini Stanson 1 & Vijay Viswanathan 3 Received: 27 May 2019 / Accepted: 12 January 2020 # Research Society for Study of Diabetes in India 2020
Abstract Background Risk factors associated with diabetes (DM) are to be well studied, and this study was aimed to investigate the family transmission pattern of type 2 DM in South Indian population. Methods A total of 3093 subjects were selected between June 2017 and May 2018. Details on family history of diabetes, treatment, and age at onset of DM were recorded. The subjects are divided into three groups based on family history risk categories maintained as registries. Group 1 (NPDR) (n = 1414) was with no parent diabetes, group 2 (OPDR) (n = 1216) with one parent diabetes, and group 3 (CPDR) (n = 463) was with both parents diabetes. The history of diabetes in siblings was recorded. Diagnosis of diabetes was confirmed based on the history of treatment and by OGTT. Results In group 2, genderwise comparison showed higher transmission of diabetes from mothers than fathers. Women had more maternal history of diabetes than paternal history [58.1 vs 41.9%; p < 0.001]. In men, the number of brothers affected by diabetes was higher than sisters (78 vs 29%; p < 0.001) whereas in women, the number of sisters affected was higher than brothers (70.3 vs 45.7%; p < 0.001). In groups 2 and 3, mean age at onset of diabetes in the subjects was one decade earlier than the mean age at onset of diabetes in parents. Conclusion Gender-specific siblings and women with maternal history of diabetes are at high risk of developing type 2 DM. Men had higher percentage of brothers affected whereas women had higher percentage of sisters affected by diabetes. The mean age at onset of diabetes in subjects was a decade earlier than mean age at onset of diabetes in their parents. Keywords Familial aggregation . Type 2 diabetes . Maternal history . Risk of diabetes . South India
Presentation in the conference:This manuscript was prepared based on our earlier work published in the “Abstracts of the 46th annual conference of Research society for the study of Diabetes in India with abstract number PD13.” This paper was presented in the 46th annual meeting of the Research Society for the Study of Diabetes in India, held at Ahmedabad between November 22 and 25, 2018 and awarded the best Poster Presentation. * Vijay Viswanathan [email protected] 1
Department of Primary Prevention of Diabetes, M.V. Hospital for Diabetes and Prof. M. Viswanathan Diabetes Research Centre, Royapuram, Chennai, Tamil Nadu, India
2
Department of Biochemistry, M.V. Hospital for Diabetes and Prof. M. Viswanathan Diabetes Research Centre, Royapuram, Chennai, Tamil Nadu, India
3
Department of Diabetology, M.V. Hospital for Diabetes and Prof. M. Viswanathan Diabetes Research Centre, No. 4, West Madha Church Street, Royapura
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