Gene Expression Systems in Fungi: Advancements and Applications
Biotechnology has emerged as one of the key environmentally safe technologies for the future which enables use of biomass to develop novel smart materials and to replace oil derived products. Fungi are the most efficient producers of the enzymes needed fo
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Monika Schmoll Christoph Dattenböck Editors
Gene Expression Systems in Fungi: Advancements and Applications
Fungal Biology
More information about this series at http://www.springer.com/series/11224
Monika Schmoll • Christoph Dattenböck Editors
Gene Expression Systems in Fungi: Advancements and Applications
Editors Monika Schmoll AIT Austrian Institute of Technology Tulln, Austria
Christoph Dattenböck AIT Austrian Institute of Technology Tulln, Austria
ISSN 2198-7777 ISSN 2198-7785 (electronic) Fungal Biology ISBN 978-3-319-27949-7 ISBN 978-3-319-27951-0 (eBook) DOI 10.1007/978-3-319-27951-0 Library of Congress Control Number: 2016932377 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
Preface
Strain improvement with fungal gene expression systems has a tradition of decades regarding modern fermentation industry and even millennia when we think of brewing processes for beer, wine or enzymatic processes in baking. Genetic engineering techniques developed in the last century have revolutionized fermentation industry and enabled production of enzyme mixtures and secondary metabolites with strongly increased efficiency, first by random mutagenesis, but soon also with knowledgebased targeted genome modification. Thereby, economic and optimized production of various compounds originating from diverse organisms became possible in filamentous fungi, from novel, thermostable, or cold active enzymes to potent antibiotics and antibodies to efficient anticancer drugs. At the same time, these possibilities opened up new challenges to be solved, like precise regulation of gene expression during the growth phase for optimized product yield and expression of heterologous proteins with unusual characteristics in a production organism. This volume aim
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