Dopamine and Gene Expression
When dopamine is released from dopaminergic neurons at the synapse, it quickly binds to its receptors that are located on dendrites or nerve terminals of target neurons as well as on dopaminergic neurons themselves. Interactions between dopamine and its r
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Springer-Verlag Berlin Heidelberg GmbH
Dopamine in the CNS 1 Contributors E. Borrelli, P. Calabresi, A. Carlsson, M. G. Caron, o. Civelli, Il Clifford, l-A. Girault, P. Greengard, S.N. Haber, B. Hermann, o. Hornykiewicz, C. laccarino, E.I Nestler, H.B. Niznik, M. Omori, C. Pifl, I-C. Schwartz, S.R. Sesack, P. Sokoloff, K.S. Sugamori, D.I Surmeier, S. Tan,A. Usiello, IL. Waddington
Editor: Gaetano Di Chiara
i
Springer
Professor GAETANO DI CHIARA
Department of Toxicology University of Cagliari Via Ospedale 72 09125 Cagliari Italy e-mail: [email protected]
With 30 Figures and 8 Tables
ISBN 978-3-642-62726-2 Library of Congress Cataloging-in-Publication Data Dopamine in the CNS/editor, Gaetano Di Chiara; contributors, E. Aquas. p. cm. - (Handbook of experimental pharmacology; 154) Includes bibliographical references and index. ISBN 978-3-642-62726-2 ISBN 978-3-642-56051-4 (eBook) DOI 10.1007/978-3-642-56051-4 1. Dopamine. 2. Central nervous system. 3. Dopaminergic mechanisms. 1. Di Chiara, Gaetano. II. Aquas, E. III. Series. QP905.H3 voI. 154 [QP364.7] 615'.1 [612.8'042 2 21]
4. Dopaminergic neurons.
2002022665
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Preface
Dopamine, like Cinderella, has come a long way since its discovery. Initially regarded as a mere precursor of noradrenaline, dopamine has progressively gained its present status of a common target for major drug classes and a substrate for some basic functions and dysfunctions of the central nervous system (CNS). A tangible sign of this status is the fact that dopamine has been the main subject of the studies of the Nobel laureates of 2000, ARVID CARLSSON and PAUL GREENGARD, who also con
