Gene Therapy for HIV and Chronic Infections
This volume examines gene therapy and gene transfer approaches to preventing or treating chronic virus infections, focusing on the Big Three viral pathogens- HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV). It explores molecular antiviral
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Ben Berkhout Hildegund C.J. Ertl Marc S. Weinberg Editors
Gene Therapy for HIV and Chronic Infections
Advances in Experimental Medicine and Biology American Society of Gene & Cell Therapy Guangping Gao, University of Massachusetts Medical School, Worcester, MA, USA Dirk Grimm, University of Heidelberg, Heidelberg, Germany
Volume 848 Editorial Board: IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy
More information about this series at http://www.springer.com/series/5584
Ben Berkhout • Hildegund C.J. Ertl Marc S. Weinberg Editors
Gene Therapy for HIV and Chronic Infections
Editors Ben Berkhout University of Amsterdam Amsterdam, The Netherlands
Hildegund C.J. Ertl The Wistar Institute University of Pennsylvania Philadelphia, PA, USA
Marc S. Weinberg University of the Witwatersrand Johannesburg, South Africa
ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-1-4939-2431-8 ISBN 978-1-4939-2432-5 (eBook) DOI 10.1007/978-1-4939-2432-5 Library of Congress Control Number: 2015932964 Springer New York Heidelberg Dordrecht London © American Society of Gene and Cell Therapy 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www. springer.com)
Preface
This book volume deals with gene therapy and gene transfer approaches to prevent or treat chronic virus infections. The focus of many chapters is on the Big Three: human immunodeficiency virus (HIV)-1, hepatitis B virus (HBV), and hepatitis C virus (HCV). HIV continues to be a major global public health concern, having claimed more than 25 million lives due to AIDS over the past three decades. In 2013, there were approximately 35 million people livin
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