Lentiviral Vectors and Gene Therapy

Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therap

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David Escors Karine Breckpot Frederick Arce Grazyna Kochan Holly Stephenson •



Lentiviral Vectors and Gene Therapy

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David Escors Division of Infection and Immunity Rayne Institute University College University Street 5 London WC1E 6JF UK

Grazyna Kochan Structural Genomics Consortium (SGC) Oxford University of Oxford Windmill Road Oxford OX3 7HE UK

Karine Breckpot Department of Physiology–Immunology Medical School Free University of Brussels Laarbeeklaan 103 1090 Jette Belgium

Holly Stephenson University College London University Street 5 London WC1E 6JF UK

Frederick Arce University College London University Street 5 London WC1E 6JF UK

ISSN 2211-9353 ISBN 978-3-0348-0401-1 DOI 10.1007/978-3-0348-0402-8

e-ISSN 2211-9361 e-ISBN 978-3-0348-0402-8

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Preface

Writing a book about lentivectors and gene therapy was certainly a challenge. During the past decades, retroviral and lentiviral vectors have moved from just academic and basic research into human clinical trials. Thus, the enormous amount of information makes it hard to select