Genes and Cardiovascular Function
Rapid advances in molecular medicine have led to pronounced new developments in experimental and clinical cardiology. In the embrace of modern molecular biology and bridging the gap between the clinical and the genomic, cardiovascular medicine has s
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Bohuslav Ostadal • Makoto Nagano Naranjan S. Dhalla Editors
Genes and Cardiovascular Function
Editors Bohuslav Ostadal, MD, DSc Professor Institute of Physiology Academy of Sciences of the Czech Republic Prague, Czech Republic [email protected]
Makoto Nagano, MD, PhD Professor Emeritus Jikei University School of Medicine Tokyo, Japan [email protected]
Naranjan S. Dhalla, PhD, MD (Hon) Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre University of Manitoba Winnipeg, Canada and Faculty of Medicine Department of Physiology University of Manitoba Winnipeg, Canada [email protected]
ISBN 978-1-4419-7206-4 e-ISBN 978-1-4419-7207-1 DOI 10.1007/978-1-4419-7207-1 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011933558 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
We are living in the era of molecular medicine and the influence of basic research on the clinical practice has never been more pronounced. Over the past 15 years, cardiovascular medicine has fully embraced the tools of modern molecular biology creating in effect a bridge between the traditional physiological and clinical discipline of cardiology and genetics, genomics and biotechnology. Moreover, there has been a widespread appreciation of the power of new advances in genetically engineered animal models and novel strategies for rapidly identifying mutations in candidate human genes for diverse cardiovascular diseases, both of which led to an exponential increase in our understanding of the molecular mechanisms that drive disease progression. Gene therapy is then one of the most fascinating consequences of the penetration of molecular biology and genetic engineering into cardiovascular medicine. It is, therefore, understandable that the interest of both experimental and clinical cardiologists in the role of genes i
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