Retrovirus Genes in Lymphocyte Function and Growth

All but one* of the following articles represent comprehensive reports on a workshop held between 7 and 9 May 1981 at the Institute of Virology and Immunobiology, University of Wfuzburg, Federal Republic of Germany. The title of the workshop was "The Invo

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Editors

w. Henle, Philadelphia· P.H. Hofschneider, Martinsried H. Koprowski, Philadelphia· F. Melchers, Basle R. Rott, GieBen· H.G. Schweiger, LadenburgiHeidelberg

PK Vogt, Los Angeles

Retrovirus Genes in Lymphocyte Function and Growth Edited by E. Wecker and I. Horak

With 8 Figures

Springer-Verlag Berlin Heidelberg New York 1982

Professor Dr. Eberhard Wecker Privatdozent Dr. Ivan Horak Institut fUr Virologie und Immunbiologie der Universitiit Wiirzburg Versbacher Str. 7 8700 Wiirzburg

ISBN-13:978-3-642-68371-8 DOl: 10.1007/978-3-642-68369-5

e-ISBN-13 :978-3-642-68369-5

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustration broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under§ 54 of the German Copyright Law where copies are made for other than private use, a fee is payable to 'Verwertungsgesellschaft', Wort, Munich. © by Springer-Verlag Berlin Heidelberg 1982. Library of Congress Catalog Card Number.

Softcover reprint of the hardcover 1st edition 1982 The use of registered names, trademarks, etc. in this publication, does nor imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Typesetting: Fotosatz Service Weihrauch, Wiirzburg Printing and binding: Universitiitsdruckerei H. Stiirtz AG, Wiirzburg 2121/3321-543210

Table of Contents

Preface.

. . .

. . . . . . . . .

. . . . VII

D.L. Steffen, H. Robinson: Endogenous Retroviruses of Mice and Chickens. . . . . . . . . . . .

1

H.L. Robinson, G.F. Vande Woude: The Genetic Basis of Retroviral-Induced Transformation. . . . . .

11

H.C. Morse III, J.W. Hartley: Expression of Xenotropic Murine Leukemia Viruses . . . . . . . .

17

E. Wecker, L Horak: Expression of Endogenous Viral Genes in Mouse Lymphocytes. . . . . .

27

E. Fleissner, H.W. Snyder, Jf.: Oncoviral Proteins as Cellular Antigens . . . . . . . . . .

37

A. Schimpl: Regulation of Lymphocyte Proliferation and Differentiation by Lymphokines . . . . . . .

81

J.N. Ihle, J.C. Lee: Possible Immunological Mechanisms in C-Type Viral Leukemogenesis in Mice

85

LL. Weissman, M.S. McGrath: Retrovirus Lymphomagenesis: Relationship of Normal Immune Receptors to Malignant Cell Proliferation . . . . . . .

103

A. Coutinho: From the Point of View of an Immunologist: Enemies from Within or Friends from Long Ago? . . . . . . . . . . . . . . .

113

R.A. Weiss: Perspectives on Endogenous Retroviruses in Normal and Pathological Growth

127

Subject Index.

133

. . . .

Indexed in Current Contents

Preface

All but one* of the following articles represent comprehensive reports on a workshop held between 7 and 9 May 1981 at the Institute of Virology and Immunobiology, University of Wfuzburg, Federal Republic of Germany. The title of the workshop was "The Involvement of Endogenous Retroviruses inN ormalFunction and Pathol