Genetic association of vascular endothelial growth factor ( VEGF ) gene variants with the risk for diabetic retinopathy:
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REVIEW ARTICLE
Genetic association of vascular endothelial growth factor (VEGF) gene variants with the risk for diabetic retinopathy: a meta-analysis Sanober Kafeel 1
&
Khan Muhammad Nangrejo 2 & Roberto Gonzalez-Salinas 3
Received: 29 July 2020 / Accepted: 15 September 2020 # Research Society for Study of Diabetes in India 2020
Abstract Introduction The vascular endothelial growth factor (VEGF) significantly contributes to the manifestation of neovascularization in the retina which progressively develops retinopathy in diabetic patients. The aim of this study was to assess the role of VEGF polymorphisms in the pathogenesis of diabetic retinopathy (DR). Methods This meta-analysis comprised a total of six case-control and cohort studies published in the last 6 years. The selection of studies was done by sorting in reliable database searches: NCBI, Ensemble, GenBank, Embase, UCSC Genome Browser. After the extraction of data, the Q test of heterogeneity was performed. The Stata Software version 13.1 was used as the statistical package. Fixed and random effect models were applied for forest plot depiction while funnel plot and Egger’s test were carried out for the evaluation of publication bias. Results A significant relationship was found between the risk allele of VEGF polymorphism rs3025039 with predisposition of DR (OR = 1.45, 95%CI = 1.04–1.86) in the absence of heterogeneity by three studies. Furthermore, significant association was also observed for four polymorphisms of VEGF (rs833061, s13207351, rs1570360, and rs2010963) with higher susceptibility of DR among the population of Pakistan (OR = 1.46, 95%CI = 1.21–1.71). Conclusion The meta-analysis suggested the substantial role of VEGF polymorphism rs3025039 as a possible biomarker for the assessment of DR risk. However, genome-wide association study (GWAS) is required in future to elucidate the multi-SNP effect of these polymorphisms in VEGF gene. Keywords Diabetic retinopathy . Meta-analysis . VEGF polymorphism . Heterogeneity
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s13410-020-00874-9) contains supplementary material, which is available to authorized users. * Sanober Kafeel [email protected] Khan Muhammad Nangrejo [email protected] Roberto Gonzalez-Salinas [email protected] 1
Dr. A. Q. Khan Institute of Biotechnology and Genetic Engineering, University of Karachi, Karachi 75270, Pakistan
2
Department of PMC Hospital, Peoples University of Medical & Health Sciences for Women, Nawabshah, Shaheed Benazirabad, Sindh 67480, Pakistan
3
Asociacion para Evitar la Ceguera en México (APEC), Vicente García Torres 46, San Lucas, 04030 Coyoacán, Ciudad de Mexico, Mexico
Introduction Diabetic retinopathy (DR) is a condition that develops in response of disturbances in the regulation of glycemia, which in turn causes an essential loss of vision among the diabetic population. According to the Atlas of the International Diabetes Federation (IDF), the current prevalence of DR in diabetes me
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