Genetic Toxicology Principles and Methods
The evaluation of potential mutagenic activity is a critical step in the assessment of the safety of both new and pre-existing chemical types. In Genetic Toxicology: Principles and Methods, expert contributors help to satisfy the demand for education in t
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IN
MOLECULAR BIOLOGY™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Genetic Toxicology Principles and Methods Edited by
James M. Parry and Elizabeth M. Parry 7, Cedar Mount, Lyndhurst, SO43 7ED, United Kingdom
Editors James M. Parry 7 Cedar Mount Lyndhurst SO43 7ED United Kingdom [email protected]
Elizabeth M. Parry 7 Cedar Mount Lyndhurst SO43 7ED United Kingdom [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-61779-420-9 e-ISBN 978-1-61779-421-6 DOI 10.1007/978-1-61779-421-6 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011942910 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface I Evaluation of potential mutagenic activity is a critical step in the assessment of the safety of both new and preexisting chemical types. Such assessments are critical in the development of new pharmaceuticals and consumer products. The UK Environmental Mutagen Society has identified an unsatisfied demand for education in the discipline of genetic toxicology, which provides the academic basis for the science behind mutagenicity testing. To provide for education in genetic toxicology, the UKEMS is sponsoring postgraduate education and the production of both electronic and printed materials. This book covers three basic areas: the scientific basis of the discipline, the methodologies of the main test assays, and the application of the methods. The text is aimed primarily at workers in the safety departments of the industries working with both natural and synthetic chemicals. Such workers need to undertake continual updating in assay methods and their application. Changes in regulations for the assessment of chemical safety in areas such as the EU are resulting in substantial increases in the demand for mutagenicity testing. We aim to provide support to both laboratory workers in providing quality information on the appropriate application of techniques and to study directors in their assay selection and protocol design. The text will provide information for both individuals undertaking personal study progra
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