Genetic Epidemiology Methods and Protocols
This volume details fast-moving research while providing in-depth descriptions of methods and analytical approaches that are helping to understand the genome and how it is related to complex diseases. Chapters guide the reader through common and rare vari
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Evangelos Evangelou Editor
Genetic Epidemiology Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Genetic Epidemiology Methods and Protocols
Edited by
Evangelos Evangelou Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece Department of Epidemiology and Biostatistics, Imperial College London, London, UK
Editor Evangelos Evangelou Department of Hygiene and Epidemiology University of Ioannina Medical School Ioannina, Greece Department of Epidemiology and Biostatistics Imperial College London London, UK
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7867-0 ISBN 978-1-4939-7868-7 (eBook) https://doi.org/10.1007/978-1-4939-7868-7 Library of Congress Control Number: 2018942871 © Springer Science+Business Media, LLC, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by the registered company Springer ScienceþBusiness Media, LLC part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Genetic epidemiology is a relatively new field of epidemiology that studies the role of genetic factors in health and diseases and has witnessed some exciting findings in our quest to understand the nature of genetic inheritance. It is an amalgam of methods and approaches applied in traditional epidemiology, statistics, genetics, and bioinformatics and it brings together several scientific disciplines. In the last few years, scientists have been able to map thousands of genetic variants contributing to complex diseases helping to unravel the genetic causes
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