Genetic variants of microRNA-146a gene: an indicator of systemic lupus erythematosus susceptibility, lupus nephritis, an
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ORIGINAL ARTICLE
Genetic variants of microRNA‑146a gene: an indicator of systemic lupus erythematosus susceptibility, lupus nephritis, and disease activity Mona E. Fouda1 · Dalia M. Nour El Din1 · Marwa Y. Mahgoub2 · Amany E. Elashkar3 · Walid A. Abdel Halim1 Received: 31 May 2020 / Accepted: 3 September 2020 © Springer Nature B.V. 2020
Abstract Genetic variations of microRNA encoding genes influence various sorts of diseases by modifying the expression or activity of microRNAs. MicroRNA 146a is an epigenetic regulator of immune response through controlling the type I interferon (IFN) and nuclear factor kappa B (NF-κB) pathways. Genetic variations of microRNA 146a impact the susceptibility to systemic lupus erythematosus (SLE) and its clinical presentations. This study aimed to investigate the polymorphisms of microRNA146a gene (rs2431697 and rs57095329) in patients with SLE and its association with disease activity. Sixty-five patients with SLE and 40 apparently healthy controls were enrolled in this study. Patients were subjected to history taking, clinical examination, and disease activity evaluation by SLEDAI score. The microRNA-146a variants were determined by allele discrimination real-time PCR method in all participants. We found a statistically significant association between rs2431697 T allele and SLE (P-value
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