Genome Editing in Neurosciences
This book is open access under a CC BY 4.0 license. Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovatio
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Rudolf Jaenisch Feng Zhang Fred Gage Editors
Genome Editing in Neurosciences
Research and Perspectives in Neurosciences
More information about this series at http://www.springer.com/series/2357
Rudolf Jaenisch • Feng Zhang • Fred Gage Editors
Genome Editing in Neurosciences
Editors Rudolf Jaenisch Whitehead Institute and Department of Biology Massachusetts Institute of Technology Cambridge, MA USA Fred Gage Laboratory of Genetics Salk Institute for Biological Studies La Jolla, CA USA
Feng Zhang Department of Brain and Cognitive Science Broad Institute of MIT and Harvard Cambridge, MA USA Fondation IPSEN Boulogne-Billancourt France
Acknowledgement: The editors wish to express their gratitude to Mrs. Mary Lynn Gage for her editorial assistance.
ISSN 0945-6082 ISSN 2196-3096 (electronic) Research and Perspectives in Neurosciences ISBN 978-3-319-60191-5 ISBN 978-3-319-60192-2 (eBook) DOI 10.1007/978-3-319-60192-2 Library of Congress Control Number: 2017948865 © The Editor(s) (if applicable) and The Author(s) 2017. This book is an open access publication. Open Access This book is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. The images or other third party material in this book are included in the book’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the book’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
It was somewhat of a surprise to the scientific community when, in 1944, Oswald Avery definitively proved that DNA encoded the blueprint to life. Many scientists at the time thoug
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