Genome Mapping and Genomics in Laboratory Animals
Mapping of animal genomes has generated huge databases and several new concepts and strategies, which are useful to elucidate origin, evolution and phylogeny. Genetic and physical maps of genomes further provide precise details on chromosomal location, fu
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Paul Denny • Chittaranjan Kole Editors
Genome Mapping and Genomics in Laboratory Animals
Editors Paul Denny Mammalian Genetics Unit Medical Research Council Harwell Oxfordshire United Kingdom
Chittaranjan Kole Institute of Nutraceutical Research Clemson University Clemson South Carolina USA
ISBN 978-3-642-31315-8 ISBN 978-3-642-31316-5 (eBook) DOI 10.1007/978-3-642-31316-5 Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2012952146 # Springer-Verlag Berlin Heidelberg 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
As a result of the development of technologies allowing access to, and analysis of, the complete genetic material of an organism, a new field of study—genomics—was established in the late twentieth century. It has flowered to encompass many different taxa, but the laboratory animals in this volume are of particular interest, because of their role as models for human disease and biology (Aitman et al. 2011). These model organisms are disparate and their adoption for scientific study was typically for pragmatic reasons, e.g., they are relatively small, have short life cycles for their particular taxonomic class, and breed well in the laborator
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