Genomic Imprinting An Interdisciplinary Approach
This book provides an unrivalled in-depth treatise of genomic imprinting, a phenomenon which plays a vital role in many biological processes in developmental biology, evolution and human diseases and genetics. The reason for this broad range of influence
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Springer-Verlag Berlin Heidelberg GmbH
Rolf Ohlsson
(Ed.)
Genomic Imprinting An Interdisciplinary Approach
With 46 Figures
Springer
Dr. R. Ohlsson Dept. of Animal Development and Genetics University of Uppsala Norbyvăgen 18 A 75236 Uppsala Sweden
ISSN 0080-1844 ISBN 978-3-662-21956-0 Library of Congress Cataloging-in-Publication Data Genomic imprinting: an interdisciplinary approach / RolfOhlsson (ed.). p. cm. - (Results and problems in cell differentiation: 25) Includes bibliographical references and index. ISBN 978-3-662-21956-0 ISBN 978-3-540-69111-2 (eBook) DOI 10.1007/978-3-540-69111-2 1. Genomic imprinting. 1. Ohlsson, R. (Rolf) II. Series. QH607.R4 voI. 25 [QH450] 571.8'35 s-dc21 [572.8'65] Library of Congress Catologing-in-Publication Data This work is subject to copyright. All rights reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-VerlagBerlin Heidelberg GmhH. Violations are liable for prosecution under the German Copyright Law. © Springer-Verlag Berlin Heidelberg 1999 OriginalIy published by Springer-VerIag Berlio Heidelberg New York in 1999 Softcover reprint of the hardcover 1st edition 1999
The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Production: PRO EOIT GmbH, 0-69126 Heidelberg Cover Concept: Meta Design, Berlin Cover Production: design & Production, 0-69121 Heidelberg Typesetting: Best-set Typesetter Ltd., Hong Kong SPIN 10647723 39/3137 - 5 4 3 2 1 0- Printed on acid-frec paper
Preface
The form and function of every living organism on the earth depends on the complex regulation of gene expression. This is carried out by controlling and interdigitating spatial and temporal patterns of gene activity during the lifetime of eukaryotic organisms. This is most dramatically apparent during early stages of development, when new types of cells and organs are being formed, often during very short time spans. To achieve this, it is vital that developmentally important genes can be kept in inactive or active states which are stably inherited in the soma. Indeed, it is now wellknown that the propensity for a gene to be transcribed or silenced is stably propagated through many cell generations, even from parent to progeny. This phenomenon constitutes a type of extragenetic or epigenetic memory of cell identity and developmental potential which has been fundamental to the evolution of complex lifeforms, such as the reader of this book. This monograph focuses on a partic
