Gestational Trophoblastic Disease Diagnostic and Molecular Genetic P
In this volume Dr Hui has brought together a comprehensive overview of gestational trophoblastic disease that includes all the currently recognized entities: complete and partial hydatidiform moles, placental site trophoblastic tumor, epithelioid trophobl
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Current Clinical Pathology Antonio Giordano, Md, Phd Series Editor
For further volumes: http://www.springer.com/series/7632
Pei Hui Editor
Gestational Trophoblastic Disease Diagnostic and Molecular Genetic Pathology
Editor Pei Hui, MD, PhD Department of Pathology Yale University School of Medicine New Haven, CT, USA [email protected]
ISBN 978-1-61779-393-6 e-ISBN 978-1-61779-394-3 DOI 10.1007/978-1-61779-394-3 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011941658 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
This book is dedicated to: Professor Bingquan Wu, M.D. An ultimate career mentor and a caring father-in-law
Foreword
In placental mammals, the trophoblast plays a critical role in the development of the embryo and fetus, and in normal circumstances is then discarded at the time of parturition, its functions fulfilled. Originating as the outer layer of the developing blastocyst, it ultimately differentiates into a diverse array of morphological phenotypes, each with highly specialized and differing functions: the cytotrophoblast functions as the stem cell component of the villous trophoblast, the syncytiotrophoblast as the terminally differentiated component that is of major importance in maternofetal exchange, and the intermediate trophoblast with multiple functions depending upon its location in villi, in the chorion laeve or in the implantation site. Not surprisingly, in diseases of the trophoblast, the different normal phenotypes are emulated to varying degrees, and the current classification of gestational trophoblastic disease is based on this structure. In this volume, Dr Hui has brought together a comprehensive overview of gestational trophoblastic disease that includes all the currently recognized entities: complete and partial hydatidiform moles, placental site trophoblastic tumor,
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