Glomerulosclerosis predicts poor renal outcome in patients with idiopathic membranous nephropathy
- PDF / 1,016,495 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 17 Downloads / 200 Views
NEPHROLOGY - ORIGINAL PAPER
Glomerulosclerosis predicts poor renal outcome in patients with idiopathic membranous nephropathy Cuimei Wei1,3 · Yongcheng He2,3 · Tong Li2,3 · Haofei Hu2,3 · Haiying Song2,3 · Dongli Qi2,3 · Yuan Cheng2,3 · Jia Chen2,3 · Mijie Guan2,3 · Xiaohua Xiao1,3 · Junyi Li4 Received: 18 March 2020 / Accepted: 7 September 2020 © The Author(s) 2020
Abstract Objective This study aimed to investigate the association between the proportion of glomerulosclerosis (focal segmental glomerulosclerosis and/or global glomerulosclerosis) and renal prognosis in patients with idiopathic membranous nephropathy (IMN). Methods A retrospective analysis performed from January 2008 to December 2017 in the First Affiliated Hospital of Shenzhen University by renal biopsy confirmed 200 patients with IMN, and their clinical pathology and prognosis were compared. Patients were divided into three groups on the basis of glomerular sclerosis proportion tertiles: low (Tertile1 group, proportion of glomerulosclerosis, 0–0%), middle (Tertile2 group, proportion of glomerulosclerosis, 0–5.5%) and high (Tertile3 group, proportion of glomerulosclerosis, 5.8–72.7%) tertiles. The follow-up endpoints were decreased estimated glomerular filtration rate (eGFR) by 20%, end-stage renal disease, and all-cause mortality. Results (1) Both, the Tertile1 and Tertile2, groups had significantly lower albumin level and higher 24-h urine protein level than that in the Tertile3 group. Regarding treatment, as the proportion of glomerulosclerosis increases, a more aggressive treatment with glucocorticoids and immunosuppressants should be provided. (2) Correlation analysis showed that the proportion of glomerulosclerosis was positively associated with age (P
Data Loading...
