Glycosignals in Cancer: Mechanisms of Malignant Phenotypes
This book is a collection of cutting-edge studies on the functions and mechanisms of glycosylation in cancers. Along with progress in genomics and proteomics, new findings in the significance of these complex carbohydrates, through the regulation of cell
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Glycosignals in Cancer: Mechanisms of Malignant Phenotypes
Glycosignals in Cancer: Mechanisms of Malignant Phenotypes
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Koichi Furukawa • Minoru Fukuda Editors
Glycosignals in Cancer: Mechanisms of Malignant Phenotypes
Editors Koichi Furukawa Department of Biochemistry II Nagoya University Graduate School of Medicine Nagoya, Aichi Japan
Minoru Fukuda Glycobiology Unit Sanford-Burnham Medical Research Institute La Jolla, California USA
ISBN 978-4-431-55937-5 ISBN 978-4-431-55939-9 DOI 10.1007/978-4-431-55939-9
(eBook)
Library of Congress Control Number: 2016930299 Springer Tokyo Heidelberg New York Dordrecht London © Springer Japan 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer Japan KK is part of Springer Science+Business Media (www.springer.com)
Preface
Along with recent progress in genomics and proteomics, new findings in the significance of complex carbohydrates in the regulation of cell signals have been elucidated in a wide variety of biological events. We may call it the real glycomics. This volume provides a comprehensive summary of glycosignals and their involvement in cancer, covering numerous topics such as glycosylation machineries, regulation of phenotypes, cell signaling, immune regulation, complex carbohydrate organization, and clinical applications. The contents have been organized to promote ready understanding, covering basic to clinical research and studies on micromolecules, to animal/human cells and tissues. This book is an essential read for students and young researchers interested in cancers and carbohydrates. Specialists in glycobiology will also benefit from the new results and approaches detailed here, which provide insights into future directions of functional studies of sugar chains in both basic and applied research. The incidence of cancers has been increasing and will keep doing so in the future. The most serious issue in our life and health, i.e., cancer, is and wil
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