Growth Hormone Deficiency Physiology and Clinical Management
Providing the most current information on the function of human growth hormone (GH) and the consequences of its deficiency, this practical yet comprehensive text is divided into three sections. Part one describes the mechanisms of GH secretion and action,
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Growth Hormone Deficiency Physiology and Clinical Management
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Growth Hormone Deficiency
Laurie E. Cohen Editor
Growth Hormone Deficiency Physiology and Clinical Management
Editor Laurie E. Cohen Boston Children’s Hospital Harvard Medical School Boston, MA, USA
ISBN 978-3-319-28036-3 ISBN 978-3-319-28038-7 DOI 10.1007/978-3-319-28038-7
(eBook)
Library of Congress Control Number: 2016936684 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface
While it has been known for close to 100 years that the pituitary gland regulates growth and for almost 60 years that human growth hormone (GH) stimulates growth in GH-deficient children, our knowledge about GH function and GH-deficient states continues to grow. Both basic science and clinical research have contributed to our understanding about GH, although the interactions between various systems are complex, and some mechanisms remain unclear. The goal of this book is to provide up-to-date information to the clinical endocrinologist on GH function and what occurs in GH deficiency. After the Introduction, the book is divided into three parts. The first describes the mechanisms of human GH secretion and action. Growth hormone structure and function are explained, along with various important regulators of GH secretion, including sex steroids and thyroid hormone. Additionally, insight into how undernutrition, inflammation, and catabolic illness affect GH secretion is discussed; as well as how the opposite state, obesity, affects GH function and testing. Included in this part are the metabolic effects of GH on body composition and on cardiovascular risk factors. The second part deals with the diagnosis of GH deficiency, both in children and in adults. It describes both the tests that can be utilized and their inter
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