Vitamin D status and response to growth hormone treatment in prepubertal children with growth hormone deficiency
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ORIGINAL ARTICLE
Vitamin D status and response to growth hormone treatment in prepubertal children with growth hormone deficiency T. Durá‑Travé1,2,3 · F. Gallinas‑Victoriano2 · P. Moreno‑González2 · M. Urretavizcaya‑Martinez2 · S. Berrade‑Zubiri2,3 · M. J. Chueca‑Guindulain2,3 Received: 13 December 2019 / Accepted: 16 March 2020 © Italian Society of Endocrinology (SIE) 2020
Abstract Purpose To analyze whether vitamin D deficiency could condition the growth response to GH therapy, as well as to analyze if GH treatment modifies both seasonal variations and vitamin D levels in these patients. Methods Retrospective study in 98 prepubertal children with GH deficiency (GHD), aged 4.1–8.9 years treated with GH. Growth rate and blood testing (calcium, phosphorus, IGF-I, 25(0H)D and PTH) were monitored at diagnostic and every six months until 24 months of treatment. A control group was recruited (247 healthy children, aged 3.8–9.7 years). The criteria of the US Endocrine Society were used for the definition of hypovitaminosis D. Results There were no significant differences in vitamin D deficiency among control (12.5%) and GHD groups (15.3%) before starting treatment. Growth rate and IGF-1 and PTH increased (p
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