Growth Hormone Related Diseases and Therapy A Molecular and Physiolo
The molecular era ushered in the cloning of the growth hormone (GH) gene and the production of unlimited amounts of GH through recombinant technology. The continuing momentum of research from basic science to clinical evaluation has brought unpreced
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Series Editor: P. Michael Conn, PhD Oregon Health & Science University Beaverton, OR, USA
For further volumes: http://www.springer.com/series/7680
Ken Ho Editor
Growth Hormone Related Diseases and Therapy A Molecular and Physiological Perspective for the Clinician
Editor Ken Ho Centres for Health Research Princess Alexandra Hospital The University of Queensland Brisbane Australia [email protected]
ISBN 978-1-60761-316-9 e-ISBN 978-1-60761-317-6 DOI 10.1007/978-1-60761-317-6 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011931862 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface
The molecular era ushered in the cloning of the growth hormone (GH) gene and the production of unlimited amounts of GH through recombinant technology. The continuing momentum of research from basic science to clinical evaluation has brought unprecedented advances to the understanding of GH biology for the clinical endocrinologist. This book endeavours to distill the new information of relevance to the endocrinologist spanning the last 20 years. It contains five sections covering physiology, molecular genetics, GH deficiency, acromegaly and pharmacotherapy. The first section on physiology focuses on GH action. A review of the structure and function of the GH receptor is followed by a perspective on the regulatory role of ghrelin on GH secretion. Attention is drawn to the pattern of GH secretion as an important determinant of tissue action. The metabolic actions of GH are diverse affecting fat, carbohydrate and protein homeostasis in humans. The second section on genetics covers pituitary function and adenomas. Transcription factors in pituitary cell type development and the disease phenotypes resulting from loss of function mutations causing isolated or combined GH deficiency are complemented by a timely review of associa
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