Growth hormones
- PDF / 141,206 Bytes
- 1 Pages / 623.591 x 841.847 pts Page_size
- 14 Downloads / 235 Views
1
S
Pancreatitis in a child?: case report A 6-year-old girl was diagnosed with idiopathic partial somatotropin deficiency and started receiving growth hormone treatment at a dosage of 25 µg/kg/day. After 2 weeks, she developed acute abdominal pain and vomiting. She was diagnosed with acute pancreatitis; she had amylase and lipase levels of 1660 U/L and 2736 U/L, respectively. Elevated lactate (45.8 mg% [sic]) and pyruvate (1 mg% [sic]) levels were revealed by diagnostic work-up. Growth hormone therapy was discontinued and her pancreatic inflammation regressed with conservative treatment. Complimentary metabolic work-up showed a mitochrondrial cytopathy; a genetic analysis confirmed a complex I deficiency (mutation T3231). Author comment: "In mitochrondrial diseases the reduced ATP production in the acinar cells could cause them to be more susceptible to autodigestion and inflammation . . . On the other hand, acute pancreatitis has been recognised as a possible complication of [growth hormone] therapy with increased enzyme production as a possible mechanism." De Beaufort C, et al. Acute pancreatitis after growth hormone treatment: disease or treatment linked? European Journal of Pediatrics 165: 652-653, No. 9, Sep 2006 801046459 Luxembourg
0114-9954/10/1121-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 30 Sep 2006 No. 1121
Data Loading...
