Testosterone overdose/growth hormones
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Kidney disease secondary to abuse: 22 case reports A prospective study described 22 men aged 18–41 years, who presented to hospital between January 2011 to December 2016 with kidney diseases, including focal segmental glomerulosclerosis (8 patients), nephroangiosclerosis (4 patients), chronic interstitial nephritis (3 patients), acute interstitial nephritis (2 patients), nephrocalcinosis/chronic interstitial nephritis (2 patients), membranous glomerulopathy (1 patient), crescentic glomerulopathy (1 patient) or sclerosing glomerulopathy (1 patient) following abuse of growth hormones, and abuse and overdose of testosterone for body-building. All men, who were body-builders, had been receiving IM injections of testosterone up to 250 mg/day, growth hormones [routes and dosages not stated] and a high-protein diet. However, after 7–49 months of exposure, the patients presented with permanent kidney diseases, which manifested as oedema, renal failure, hypertension, fluid overload, headache, elevated calcium or combinations thereof. Subsequent histopathology findings led to the diagnosis of focal segmental glomerulosclerosis (8 patients), nephroangiosclerosis (4 patients), chronic interstitial nephritis (3 patients), acute interstitial nephritis (2 patients), nephrocalcinosis/chronic interstitial nephritis (2 patients), membranous glomerulopathy (1 patient), crescentic glomerulonephritis (1 patient) or sclerosing glomerulonephritis (1 patient), which were attributed to abuse of growth hormones, and abuse and overdose of testosterone. All 22 men eventually progressed to chronic renal failure. All men were subsequently instructed to consume lowprotein diets, and to avoid testosterone, growth hormones and NSAIDs. Thereafter, 8 men experienced improvement in kidney disease, whereas the remaining patients experienced persistence of their kidney diseases. Author comment: "[W]e present the renal outcome in 22 patients who presented with renal disease associated with use of [testosterone] and [growth hormones]". "[Testosterone and growth hormones] are internationally banned and their intake is considered abuse." "[T]he usual dose testosterone replacement therapy hardly exceeds 250 mg IM every three weeks. Our patients had consumed pharmacological doses of such drug reaching up to 100 times the usual therapeutic one". El-Reshaid W, et al. Complementary bodybuilding: A potential risk for permanent kidney disease. Saudi Journal of Kidney Diseases and Transplantation 29: 326-331, No. 2, 2018. Available from: URL: http://doi.org/10.4103/1319-2442.229269 803433913 Kuwait
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Reactions 16 Nov 2019 No. 1779
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