HCV: The Journey from Discovery to a Cure Volume I
Hepatitis C is a liver disease caused by the hepatitis C virus (HCV) and infects approximately 75 million individuals worldwide. It is also one of the major causes of liver cancer and liver transplants. The elucidation of the HCV genome, and the developme
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Michael J. Sofia Editor
HCV: The Journey from Discovery to a Cure Volume I
31
Topics in Medicinal Chemistry
Series Editors P.R. Bernstein, Philadelphia, USA A.L. Garner, Ann Arbor, USA G.I. Georg, Minneapolis, USA T. Kobayashi, Tokyo, Japan J.A. Lowe, Stonington, USA N.A. Meanwell, Princeton, USA A.K. Saxena, Lucknow, India U. Stilz, Boston, USA C.T. Supuran, Sesto Fiorentino, Italy A. Zhang, Pudong, China
Aims and Scope Topics in Medicinal Chemistry (TMC) covers all relevant aspects of medicinal chemistry research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. To fulfil this need, TMC is intended for researchers and experts working in academia and in the pharmaceutical industry, and also for graduates that look for a carefully selected collection of high quality review articles on their respective field of expertise. Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. All chapters from Topics in Medicinal Chemistry are published OnlineFirst with an individual DOI. In references, Topics in Medicinal Chemistry is abbreviated as Top Med Chem and cited as a journal.
More information about this series at http://www.springer.com/series/7355
Michael J. Sofia Editor
HCV: The Journey from Discovery to a Cure Volume I
With contributions by S. A. Alqahtani H. J. Alter R. Bartenschlager E. Billerbeck H.-J. Chen A. Cho P. A. Furman Y. Gai R. G. Gentles C. S. Graham M. Houghton L.-J. Jiang D. Kempf Y.-Y. Ku A. D. Kwong N. J. Liverton V. Lohmann J. Long J. Ma J. A. McCauley K. F. McDaniel N. A. Meanwell T. Middleton Y. S. Or R. B. Perni R. Rajamani C. M. Rice M. T. Rudd M. Saeed P. M. Scola J. Shanley M. J. Sofia L.-Q. Sun Y. Sun M. S. Sulkowski J. G. Taylor S. Venkatraman B. Wang G. Wang W. J. Watkins
Editor Michael J. Sofia Arbutus Biopharma, Inc. Warminster, PA, USA
ISSN 1862-2461 ISSN 1862-247X (electronic) Topics in Medicinal Chemistry ISBN 978-3-030-28206-6 ISBN 978-3-030-28207-3 (eBook) https://doi.org/10.1007/978-3-030-28207-3 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserv
