Heart Failure Management: The Neural Pathways
This book describes the most recent insights into heart failure and the role played by autonomic nervous system pathophysiology in it, discussing the therapeutic implications. While current therapeutic approaches are able to control the effects of excessi
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Edoardo Gronda Emilio Vanoli Alexandru Costea Editors
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Heart Failure Management: The Neural Pathways
Edoardo Gronda • Emilio Vanoli Alexandru Costea Editors
Heart Failure Management: The Neural Pathways
Editors Edoardo Gronda IRCCS MultiMedica Sesto San Giovanni Milan Italy
Alexandru Costea University of Cincinnati Cincinnati Ohio USA
Emilio Vanoli IRCCS MultiMedica Sesto San Giovanni Milan Italy Department of Molecular Cardiology University of Pavia
ISBN 978-3-319-24991-9 ISBN 978-3-319-24993-3 DOI 10.1007/978-3-319-24993-3
(eBook)
Library of Congress Control Number: 2015960204 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
Foreword
The idea of the brain being in command and the heart housing the soul, distracts from the actual primary director of our life: the autonomic nervous system (ANS). It drives breathing, heartbeat, and any other aspect of being alive. Heart transplantations had shown that the removed heart was able to function properly without innervation. In early 1960, however, a major shift occurred in the understanding of the autonomic control of the heart by the discovery of its specialized and detailed control of all aspects of the cardiovascular system. Specific areas were described in the central nervous system with “highly specialized and sharply localized capacities for regional control of myocardial function” (Randall WC 1977). The evidence that parasympathetic fibers were distributed in the ventricles overcame the dogma that the cardiac vagal control was limited to the supraventricular structures. In 1977, Randall edited a first comprehensive book Neural Regulation of the Heart that still stands as a masterpiece in this field. In that period, Italy was one of the most fertile cradles in the field
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