Heart Hypertrophy and Failure
Heart Hypertrophy and Failure brings together leading basic scientists and clinicians, presenting improved knowledge of the pathophysiology and treatment of the condition. The result is a synthesis of state-of-the-art information on molecular biology, cel
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DEVELOPMENTS IN CARDIOVASCULAR MEDICINE 121. S. Sideman, R. Beyar and A.G. Kleber (eds): Cardiac Electrophysiology, Circulation, and Transport. Proceedings of the 7th Henry Goldberg Workshop (Berne, Switzerland, 1990). 1991. ISBN 0-7923-1145-0. 122. D.M. Bers: Excitation-Contraction Coupling and Cardiac Contractile Force. 1991. ISBN 0-7923-1186-8. 123. A.-M. Salmasi and A.N. Nicolaides (eds): Occult Atherosclerotic Disease. Diagnosis, Assessment and Management. 1991. ISBN 0-7923-1188-4. 124. JA.E. Spaan: Coronary Blood Flow. Mechanics, Distribution, and Control. 1991. ISBN 0-7923-1210-4. 125. R.W. Stout (ed): Diabetes and Atherosclerosis. 1991. ISBN 0-7923-1310-0. 126. A.G. Herman (ed): Antithrombotics. Pathophysiological Rationale for Pharmacological Interventions. 1991. ISBN 0-7923-1413-1. 127. N. H.J. Pijls: Maximal Myocardial Perfusion as a Measure of the Functional Significance of Coronary Arteriogram. From a Pathoanatomic to a Pathophysiologic Interpretation of the Coronary Arteriogram. 1991. ISBN 0-7923-1430-1. 128. JH.C. Reiber and E.E. v.d. Wall (cds): Cardiovascular Nuclear Medicine and MRI. Quantitation and Clinical Applications. 1992. ISBN 0-7923-1467-0. 129. E. Andries, P. Brugada and R. Stroobrandt (eds): How to Face "the Faces" of Cardiac Pacing. 1992. ISBN 0-7923-1528-6. 130. M. Nagano, S. Mochizuki and N.S. Dhalla (eds): Cardiovascular Disease in Diabetes. 1992. ISBN 0-7923-1554-5. 131. P. W. Serruys, B.H. Strauss and S.B. King III (cds): Restenosis after Intervention with New Mechanical Devices. 1992. ISBN 0-7923-1555-3. 132. P.J. Walter (cd): Quality of Life after Open Heart Surgery. 1992. ISBN 0-7923-1580-4. 133. E.E. van der Wall, H. Sochor, A. Righetti and M.G. Niemeyer (cds): What is new in Cardiac Imaging? SPECT, PET and MRI. 1992. ISBN 0-7923-1615-0. 134. P. Hanrath, R. Uebis and W. Krebs (cds); Cardiovascular Imaging by Ultrasound. 1992. ISBN 0-7923-1755-6. 135. F.H. Messerli (cd): Cardiovascular Disease in the Elderly, 3rd cd. 1T C I -> T CI~T T2~G
GI -> G I -> G , ...... A2 -> G 2 -> C I ->
C A T C A G
GI~A
G , -> A G , -> A G , -> A Deletion
Amino acids Ala 26 =;. Val Arg 54 =;. Stop Val 59 =;. lie Thr l24 =;. lie Arg 14.1 =;. GIn Tr/ 62 =;. Cys Asn lH7 =;. Lys Asn 232 =;. Scr Arg 249 =;. GIn Gl y 256 =;. Glu Arg403 =;. GIn A rg 4(13 =;. Leu Arg403 =;. Trp Arg 453 =;. Cys Phe 513 =;. Cys Gl y5H4 =;. Arg ASp587 =;. Val Asn 602 =;. Ser Val 606 =;. Met Lys 615 =;. Asn Gl y716 =;. Arg Arg 719 =;. Trp Arg 723 =;. Cys pro73 I =;. Leu lIe 736 =;. Met Gl y 741 =;. Arg Gl y741 =;. Arg Gl y741 =;. Trp Asp 778 =;. Gly ArgH70 =;. His Leu 90S =;. Val Gl u924 =;. Lys Glu 930 =;. Lys GIU 935 =;. Lys Glu 949 =;. Lys Gl y '93'_LclI_Asn_ Glu-Glu I'))5
Troponin T genc
Nucleotides
Amino acids
Exon 8 Exon 9 Intron 15
T->A G->A G->A
lIe79 =;. Asn Arg 92 =;. Glu Loss of 28 terminal amino acids
gene
N lIcleotides
Amino acids
Exon 5 Exon 5
G->A
Asp 175 =;. Asn Glu ISO =;. Gly
a Tropomyosin
A~G
1. Molecular analysis of genotype/phenotype correlations of hypertrophic cardiomyopathy
7
descr
