Heat Shock Factor
This book presents a large amount of information related to the heat shock response and heat shock factor (HSF), describes core observations about molecular mechanisms and pathophysiological roles, and provides fundamental concepts on the basis of informa
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Heat Shock Factor
Heat Shock Factor
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Akira Nakai Editor
Heat Shock Factor
Editor Akira Nakai Department of Biochemistry and Molecular Biology Yamaguchi University School of Medicine Ube, Japan
ISBN 978-4-431-55850-7 ISBN 978-4-431-55852-1 DOI 10.1007/978-4-431-55852-1
(eBook)
Library of Congress Control Number: 2015958662 Springer Tokyo Heidelberg New York Dordrecht London © Springer Japan 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer Japan KK is part of Springer Science+Business Media (www.springer.com)
Preface
All organisms sense varying conditions in the environment that they live in, and respond and ultimately adapt to them through sophisticated mechanisms. These adaptive mechanisms play pivotal roles for homeostasis and biological defense; therefore, the elucidation of the adaptive mechanisms has grown to be major research field in molecular biology. A prominent system among them is a primitive and evolutionally conserved adaptive mechanism called heat shock response, which induces the heat shock proteins against proteotoxic stress including high temperature. It has been 53 years since the discovery of the heat shock response (in 1962), and 27 years after the molecular cloning of the key regulator, heat shock factor (HSF) (isolated in 1988). This adaptive response to high temperature or protein misfolding is a fundamental mechanism to maintain the capacity of protein homeostasis, or proteostasis, and is evolutionally conserved among all living organisms, including bacteria and humans, on the earth. Furthermore, physiological and pathological roles of HSF have been extensively studied in fruit fly, worm, and mouse models for the last 18 years (starting in 1997). It has been revealed that HSF plays roles in development of the brain, reproductive and sensory organs, and in ageing, inflammation, and circadian rhythm. Analysis of the mechanisms have uncovered that HSF exerts a wide range of effec
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