Heat Shock Proteins and Pain
Pain, especially chronic pain, is a health issue affecting about one-third of the population all over the world. The sensitization of pain is highly associated with inflammatory responses to tissue damage and other harmful signals. The heat shock proteins
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Abstract Introduction Pain, especially chronic pain, is a health issue affecting about one-third of the population all over the world. The sensitization of pain is highly associated with inflammatory responses to tissue damage and other harmful signals. The heat shock proteins (HSP) have been demonstrated to play central rolesin the inflammatory responses and pain via regulating the protein folding, maturation, activation, and degradation of proteins in varioussignal pathways. The objective of this chapter was to summarize the role of HSP in pain and pain drug-induced signal pathways and antinociception. Methods The authors reviewed papers of different HSP with an emphasis on pain and pain management. Results We highlight some basic concepts of pain and inflammatory responses, discuss the impact of inflammatory mediators, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha (TNF-α), on the sensitization of pain. We also summarize the role of HSP in different types of pain in animal models and human diseases and discuss the impact of HSP on pain drug-induced signalsand behavior. Conclusions HSP are highly involved in pain and pain treatment and could be targeted for improving therapeutic outcomes, even though the exact mechanisms remain unclear. Keywords Cytokine · Heat shock protein · Inflammation · Kinase · Opioid · Pain
X. Chen (*) · A. Smith · C. Plummer · W. Lei (*) Department of Pharmaceutical and Administrative Sciences, School of Pharmacy, Presbyterian College, Clinton, SC, USA e-mail: [email protected]; [email protected] © Springer Nature Switzerland AG 2020 A. A. A. Asea, P. Kaur (eds.), Heat Shock Proteins in Neuroscience, Heat Shock Proteins 20, https://doi.org/10.1007/7515_2020_20
X. Chen et al.
Abbreviations 17-DMAG Bdnf BiP CCI CGRP cHsp60 CLR CNS COX CP CP/CPPS DAMP DRG ELISA EP1 ER ERK GAPDH Grp HDAC6 Hsc Hsp IL-1β IL-6 iNOS JAK-STAT MAPK MD-2 MEF2 MEK2 MOR NF-κB NLR NOS PAMP PCR PGE2 PID PKC PNS PRR
17-Dimethylaminoethylamino-17-demethoxygeldanamycin brain-derived neurotrophic factor binding immunoglobulin protein chronic constriction injury calcitonin-gene-related peptide C. trachomatis Hsp60 c-type lectin receptor central nervous system cyclooxygenase enzymes chronic bacterial prostatitis chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome danger-associated molecular pattern dorsal root ganglion enzyme-linked immunosorbent assay Prostaglandin E2 receptor 1 endoplasmic reticulum extracellular signal-regulated kinase glyceraldehyde-3-phophate-dehyrogenase glucose-regulated protein histone deacetylase 6 heat shock cognate heat shock protein interleukin (IL)-1 beta interleukin 6 inducible nitric oxide synthase Janus kinase-signal transducer and activator of transcription mitogen-activated protein kinase myeloid differentiation factor 2 myocyte enhancer factor 2 mitogen-activated protein kinase kinase 2 mu opioid receptor nuclear factor kappa-B NOD-like receptor nitric oxide synthase pathogen-associated molecular pattern molecule polymerase chain reaction pros
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