Heat Shock Protein 90 in Human Diseases and Disorders
The book Heat Shock Protein 90 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP90. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, previously unknow
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Alexzander A. A. Asea Punit Kaur Editors
Heat Shock Protein 90 in Human Diseases and Disorders
Heat Shock Proteins Volume 19
Series editors Alexzander A. A. Asea Professor, Department of Medicine and Director Precision Therapeutics Proteogenomics Diagnostic Center Eleanor N. Dana Cancer Center University of Toledo, College of Medicine and Life Sciences Toledo, USA Stuart K. Calderwood Professor and Director, Division of Molecular and Cellular Radiation Oncology Department of Radiation Oncology Beth Israel Deaconess Medical Center and Harvard Medical School Boston, USA
Heat Shock Proteins: key mediators of Health and Disease. Heat shock proteins (HSP) are essential molecules conserved through cellular evolution required for cells to survive the stresses encountered in the environment and in the tissues of the developing and aging organism. These proteins play the essential roles in stress of preventing the initiation of programmed cell death and repairing damage to the proteome permitting resumption of normal metabolism. Loss of the HSP is lethal either in the short-term in cases of acute stress or in the long-term when exposure to stress is chronic. Cells appear to walk a fine line in terms of HSP expression. If expression falls below a certain level, cells become sensitive to oxidative damage that influences aging and protein aggregation disease. If HSP levels rise above the normal range, inflammatory and oncogenic changes occur. It is becoming clear that HSP are emerging as remarkably versatile mediators of health and disease. The aim of this series of volumes is to examine how HSP regulation and expression become altered in pathological states and how this may be remedied by pharmacological and other interventions. More information about this series at http://www.springer.com/series/7515
Alexzander A. A. Asea • Punit Kaur Editors
Heat Shock Protein 90 in Human Diseases and Disorders
Editors Alexzander A. A. Asea Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center University of Toledo, College of Medicine and Life Sciences Toledo, OH, USA
Punit Kaur Department of Experimental Radiation Oncology MD Anderson Cancer Center Houston, TX, USA
ISSN 1877-1246 ISSN 1877-1254 (electronic) Heat Shock Proteins ISBN 978-3-030-23157-6 ISBN 978-3-030-23158-3 (eBook) https://doi.org/10.1007/978-3-030-23158-3 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the abs
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