Hematological reference intervals among full-term newborns in Ethiopia: a cross-sectional study
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RESEARCH ARTICLE
Open Access
Hematological reference intervals among full-term newborns in Ethiopia: a crosssectional study Tegenaw Tiruneh*, Teklehaimanot Kiros and Sisay Getu
Abstract Background: Hematological reference intervals are used for medical decision tools for interpretation of numerical test results. Establishing of hematological interval among newborn babies is very important for the diagnosis of malignancy, anemia, bleeding disorders, and various infections. There are no locally established hematological reference intervals in Ethiopia. Thus, the aim of this study is to establish locally determined hematological reference interval among full-term newborns. Methods: A cross-sectional study was conducted from May 15 to July 30 2019 among 151 apparently healthy fullterm newborns at Gondar University Hospital. About 3 ml of cord blood was obtained for analysis of Hematological parameters and determined by using Sysmex KX-21N (Sysmex Corporation Kobe, Japan) automated analyzer. Median, 2.5th and 97.5th percentile were computed. Result: Male to female ratio was almost equal. All hematological parameter had no statistically significant difference between males and females. The delivery types were not influenced its hematological values. The reference interval of white blood cells, red blood cells, platelets, hemoglobin, hematocrit, mean cell volume, and mean cell hemoglobin were (7.64–22.16) x109/l, (3.69–5.47)x1012/l, (132.74–413.4) x109/l, (13.32–19.64) g/dl and (39.42–58.06)%, (91.6-113.22)fl, and (30.48–38.02 pg), respectively. Conclusions: All hematological reference intervals were established from full-term newborns at University of Gondar hospital was different from other studies in Nigeria, Iraq, Pakistan, Nepal, Saudi Arabia and Iran. Therefore, own determined reference value is very important for the clinicians to correctly diagnosis the patients at health facility levels. Keywords: Hematological reference interval, newborns, Debre Tabor, Ethiopia
Introduction Background
Umbilical cord blood (UCB) is the blood remaining after in the excluding of the placenta. It is considered as biological waste products. However, it has many advantages like stem cell transplantation (rich in hematopoietic progenitor and stem cells), Rhesus factor (Rh) blood typing of the newborns, * Correspondence: [email protected] College of Health Sciences, Department of Medical Laboratory Science, Debre Tabor University, Debre Tabor, Ethiopia
assessment of the neonatal thrombocytopenia or thrombosis, screening and diagnosis of anemia, polycythemia, bacterial sepsis and determination of hematological reference interval (RI) [1–3]. The other main advantage of UCB is to minimize blood draw from very ill newborns that cause increased morbidity and mortality during neonatal life. The UCB is the alternative source to eliminate unwanted, repeated blood drawn for laboratory tests. The collection of UCB is safe for the patients and technically easy as compared to other blood collection sites [4].
© The Author(s). 2020 Open Acce
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