Capillary blood reference intervals for platelet parameters in healthy full-term neonates in China
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RESEARCH ARTICLE
Open Access
Capillary blood reference intervals for platelet parameters in healthy full-term neonates in China Dongyan Cui1†, Yan Hou2†, Ling Feng3, Guo Li4, Chi Zhang4, Yanli Huang5, Jiubo Fan6 and Qun Hu1*
Abstract Background: No consensus has been reached on capillary blood reference intervals for platelet parameters in fullterm neonates. We aimed to establish neonatal capillary blood reference intervals for platelet parameters and evaluate influences of sex, gestational age and postnatal age on platelet parameters. Methods: This study was a prospective investigation and implemented in 594 healthy full-term neonates from 12 to 84 h of age, using SYSMEX XN-9000 haematology automatic analyser by means of capillary blood. Reference intervals for platelet parameters were defined by an interval of 2.5th − 97.5th percentiles. Results: Capillary reference interval for platelet count was (152–464) × 109/L. No significance was found between sex-divided reference intervals for platelet parameters. The values of platelet count changed minimally across gestational age (37–41 weeks) and postnatal age (12–84 h). Reference intervals for other platelet parameters were affected by these factors to a different extent. Conclusions: We established capillary blood reference intervals for platelet parameters in the first days after birth of full-term neonates in China. Keywords: Neonates, Capillary blood, Platelet count, Platelet parameters, Reference intervals
Background Reference intervals (RIs) play a critical role in clinical practice. Appropriate RIs for platelet parameters ensure clinical laboratories provide reliable information and enable clinicians to correctly interpret results and further determine whether transfusions are needed for neonates [1, 2]. However, few normative data are available in RIs for platelet parameters in full-term neonates [3] Neonates are in a crucial period of rapid development, and platelet parameters are significantly affected by these physiological changes [4]. Moreover, RIs for platelet * Correspondence: [email protected] † Dongyan Cui and Yan Hou contributed equally to this work. 1 Department of Paediatric Haematology and Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People’s Republic of China Full list of author information is available at the end of the article
parameters have often been derived from haematological results of both inpatient and outpatient neonates [4, 5], or blood samples are leftover material from the donated blood for a specific use in a pre-term (delivered at less than 37 weeks of gestation) or full-term neonate population [6, 7], which may be inaccurate and unreliable for full-term neonates. It is hard for neonatal health care providers to provide standard-of-care health services as a lack of appropriate RIs for haematology may impede diagnostics for neonates [8]. The study of RIs for platelet parameters in neonates is highly restricted due to the ethical limitations and
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