Hemostasis and Thrombosis
The latest edition of this practical handbook provides a concise yet comprehensive overview of common and rare problems with hemostasis and thrombosis. Through thoroughly updated and revised chapters, the text features practical information on diagnosing
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Hemostasis and Thrombosis
Thomas G. DeLoughery Editor
Hemostasis and Thrombosis Fourth Edition
Editor Thomas G. DeLoughery Division of Hematology/Medical Oncology Oregon Health & Sciences University Portland, OR USA
ISBN 978-3-030-19329-4 ISBN 978-3-030-19330-0 (eBook) https://doi.org/10.1007/978-3-030-19330-0 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Contents
1 Basics of Coagulation���������������������������������������������������������������������� 1 Thomas G. DeLoughery 2 Tests of Hemostasis and Thrombosis���������������������������������������������� 11 Thomas G. DeLoughery 3 Bleeding Disorders: A General Approach ������������������������������������ 19 Thomas G. DeLoughery 4 Hemophilia��������������������������������������������������������������������������������������� 23 Thomas G. DeLoughery 5 Von Willebrand Disease������������������������������������������������������������������ 33 Thomas G. DeLoughery 6 Other Inherited Bleeding Disorders���������������������������������������������� 39 Thomas G. DeLoughery 7 Acquired Bleeding Disorders���������������������������������������������������������� 45 Thomas G. DeLoughery 8 Disseminated Intravascular Coagulation�������������������������������������� 55 Thomas G. DeLoughery 9 Liver and Renal Disease������������������������������������������������������������������ 61 Thomas G. DeLoughery 10 Cardiac Bypass and Ventricular Assist Devices/ECMO�������������� 67 Thomas G. DeLoughery 11 Immune Thrombocytopenia������������������������������������������������������������ 73 Thomas G. DeLoughery 12 Thrombotic Microangiopathy (TTP/HUS)���������������
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