Hepatitis B Virus in Human Diseases
This text provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for students, clinicians, and researchers with an interest in hepatitis B. The book reviews new data about basic and translational scien
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Yun-Fan Liaw Fabien Zoulim Editors
Hepatitis B Virus in Human Diseases
Molecular and Translational Medicine
Series Editors William B. Coleman Gregory J. Tsongalis
More information about this series at http://www.springer.com/series/8176
Yun-Fan Liaw • Fabien Zoulim Editors
Hepatitis B Virus in Human Diseases
Editors Yun-Fan Liaw Chang Gung University Chang Gung Memorial Hospital Taipei, Taiwan
Fabien Zoulim Cancer Research Center of Lyon INSERM Unit 1052 Lyon University Hospices Civils de Lyon Lyon, France
ISSN 2197-7852 ISSN 2197-7860 (electronic) Molecular and Translational Medicine ISBN 978-3-319-22329-2 ISBN 978-3-319-22330-8 (eBook) DOI 10.1007/978-3-319-22330-8 Library of Congress Control Number: 2015955725 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
Foreword
The publication of “Hepatitis B virus in Human Diseases” coincides with the fiftieth anniversary of the discovery of the virus [1]. This is a good time, therefore, to reflect on where we have come from, and are going. We now know that Hepatitis B virus (HBV) is a small DNA virus that has chronically infected hundreds of millions of people worldwide and is responsible for nearly a million liver disease-related deaths a year [2, 3]. However, it is worth noting that the discovery of hepatitis B was not an obvious one, but was made in a very exciting time. Although science progressed with great speed in the 1940s, 1950s, and early 1960s, most of this progress was in molecular biology, as compared with medical science. For example, and to put the period in context, DNA was identified as the information molecule in all cells [4] and its structure of DNA was solved by Watson and Crick [5]. The genetic code was translated by Nirenb
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