Hepatitis B virus infection and diabetes mellitus: the Kailuan prospective cohort study in China
- PDF / 1,181,575 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 61 Downloads / 194 Views
ORIGINAL ARTICLE
Hepatitis B virus infection and diabetes mellitus: the Kailuan prospective cohort study in China Shaoyuan Lei1 · Shuohua Chen2 · Xinyu Zhao1 · Yanmin Zhang3 · Kailiang Cheng1 · Xiaohui Zhang4 · Zhenyu Wang1 · Yuanyuan Sun1 · Shouling Wu5 · Li Wang1 Received: 15 April 2020 / Accepted: 20 August 2020 © Asian Pacific Association for the Study of the Liver 2020
Abstract Background and aims The effect of hepatitis B virus (HBV) infection on diabetes has remained unclear. We thus conducted a prospective cohort study to investigate the association between different HBV infection status and new-onset diabetes in a Chinese population. Methods We enrolled 55,520 participants with HBV serological markers and diabetes free in 2010 in Kailuan cohort. Cox regression models were used to analyze the relationship between different HBV infection status and incidence of diabetes after adjusting different confounders. Results During an average follow-up of 5.6 years, we identified 6008 incident patients with diabetes. Compared to the participants with hepatitis B surface antigen (HBsAg) negative/hepatitis B surface antibody (anti-HBs) negative/hepatitis B core antibody (anti-HBc) negative, those with chronic HBV infection or with HBsAg negative/anti-HBc positive had a higher risk to occur diabetes. The hazard ratios were 1.18 (95% CI 0.99–1.40, p = 0.0588) and 1.22 (95% CI 1.08–1.36, p = 0.0009), respectively. The association between chronic HBV infection, anti-HBc positive and diabetes was different between those with different levels of high density lipoprotein cholesterol, blood pressure, body mass index, and age. Conclusion The individuals with chronic HBV infection or anti-HBc positive may have an increased risk of diabetes, and the association may be modified by the different status of metabolism related variables and age. Effective management of HBV infection may contribute to the reduction of the burden of both hepatitis B and diabetes. Keywords Diabetes · Hepatitis B virus · Hepatitis B surface antigen · Hepatitis B surface antibody · Hepatitis B core antibody · Cohort · Chinese · High density lipoprotein cholesterol · Blood pressure · Triglyceride · Body mass index
Shaoyuan Lei and Shuohua Chen have contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12072-020-10086-2) contains supplementary material, which is available to authorized users.
Abbreviations ALT Alanine aminotransferase Anti-HBe Hepatitis B e antibody Anti-HBc Hepatitis B core antibody Anti-HBs Hepatitis B surface antibody BMI Body mass index CI Confidence interval DM Diabetes mellitus
* Shouling Wu [email protected]
3
Gastroenterology Department, Kailuan General Hospital, Tangshan 063001, China
* Li Wang [email protected]
4
Physical Examination Center, Linxi Hospital of Kailuan General Hospital, Tangshan 063001, China
5
Cardiology Department, Kailuan General Hospital, Tangshan 063000, China
1
Department of Epidemiology and
Data Loading...
