High CENPM mRNA expression and its prognostic significance in hepatocellular carcinoma: a study based on data mining
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RIMARY RESEARCH
Cancer Cell International Open Access
High CENPM mRNA expression and its prognostic significance in hepatocellular carcinoma: a study based on data mining Zeng‑hong Wu and Dong‑liang Yang*
Abstract Background: Hepatocellular carcinoma (HCC) is a high mortality disease, the fifth most general cancer worldwide, and the second leading to cancer-related deaths, with more than 500,000 new patients diagnosed each year. First, the high expression of centromere M (CENPM) in mammary gland tissue of b-catenin transformed mice was identified. Materials and methods: In our study, we evaluated the expression of CENPM in hepatocellular carcinoma based on data obtained from an online database. Multivariate analysis showed that the expression of CENPM and M classifica‑ tion was an independent prognostic factor for patients with hepatocellular carcinoma. Results: Survival analysis showed that patients with high CENPM had a worse prognosis than patients with low CENPM (P
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