High detection sensitivity and reliable morphological correlation of PET with a silicon photomultiplier for primary tong
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ORIGINAL ARTICLE
High detection sensitivity and reliable morphological correlation of PET with a silicon photomultiplier for primary tongue squamous cell carcinoma Ikuho Kojima1,4 · Kentaro Takanami2 · Takenori Ogawa3,4 · Maya Sakamoto1,4 · Hirokazu Nagai4,5 · Hitoshi Miyashita4,5 · Masahiro Iikubo1,4 Received: 22 April 2020 / Accepted: 12 June 2020 © The Japanese Society of Nuclear Medicine 2020
Abstract Objective A positron emission tomography (PET) scanner using a silicon photomultiplier (SiPM PET) in place of a photomultiplier tube significantly improves the spatial and time resolution. It may also improve the evaluation of smaller lesions compared to conventional (non-SiPM) PET scanners. We compared the maximum standardized uptake value ( SUVmax), detection sensitivity, and morphological correlation using magnetic resonance imaging (MRI) for primary tongue squamous cell carcinoma between the SiPM PET and non-SiPM PET scanner. Methods We retrospectively reviewed the F-18 fluorodeoxyglucose (FDG) PET/CT features of tongue squamous cell carcinomas in consecutive, newly diagnosed, and pathologically verified patients. Twenty-five of 46 patients were scanned using SiPM PET scanner and the remaining 21 patients were scanned with a non-SiPM PET scanner. We compared the S UVmax and visual evaluation of primary tumor detectability, and the correlation between the PET-based and MRI-based tumor size (long axis, thickness, and volume). Differences in S UVmax and detection sensitivity for the primary tumor were analyzed using Welch’s t test and Fisher’s exact test, respectively. Correlations among the PET-based, MRI-based tumor size, and SUVmax were assessed using Spearman’s rank correlation coefficient. Results SUVmax of both T1/T2 and T3/T4 primary tumors were significantly higher for the SiPM PET (T1/T2 mean SUVmax: 6.6 ± 4.3, T3/T4 mean S UVmax: 18.2 ± 9.8) than that for the non-SiPM PET (T1/T2 mean SUVmax: 3.4 ± 1.4, T3/T4 mean SUVmax: 10.2 ± 4.9) (P
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