High FDG uptake on PET is associated with negative cell-to-cell adhesion molecule E-cadherin expression in lung adenocar
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ORIGINAL ARTICLE
High FDG uptake on PET is associated with negative cell-to-cell adhesion molecule E-cadherin expression in lung adenocarcinoma Kotaro Higashi1 • Yoshimichi Ueda2 • Miyako Shimasaki2 • Yasuhito Ishigaki3 Yuka Nakamura3 • Manabu Oguchi4 • Tsutomu Takegami3 • Naoto Watanabe5
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Received: 14 May 2017 / Accepted: 29 June 2017 Ó The Japanese Society of Nuclear Medicine 2017
Abstract Objectives E-cadherin is a main cell-to-cell adhesion molecule. A negative expression of E-cadherin correlates with distant metastasis in lung cancer. Recently, it was reported that there is an association between FDG uptake on PET and epithelial-mesenchymal transition (EMT) in non-small cell lung cancer. Downregulation of E-cadherin is one of the best markers of EMT. The purpose of this study was to compare E-cadherin expression with FDG uptake on PET, cell differentiation, aggressiveness and post-operative recurrence in patients with lung adenocarcinoma, and to investigate whether FDG uptake on PET is associated with E-cadherin expression. Methods We retrospectively reviewed 40 lung adenocarcinoma patients who underwent thoracotomy and FDG PET before thoracotomy. These patients were evaluated FDG PET metrics such as standardized uptake value (SUV), the immunohistochemical expression of E-cadherin in surgical specimens, clinicopathological features, including tumor size, pathologic stage, cell differentiation, aggressiveness and post-operative recurrence. & Kotaro Higashi [email protected] 1
2
Department of Radiology, Asanogawa General Hospital, 83 Kosakamachi-Naka, Kanazawa, Ishikawa 920-8621, Japan Department of Pathology, Kanazawa Medical University, Kanazawa, Ishikawa, Japan
3
Medical Research Institute, Kanazawa Medical University, Kanazawa, Ishikawa, Japan
4
Department of Radiation Therapy, Public Central Hospital of Matto Ishikawa, Kanazawa, Japan
5
Department of Radiology, Kanazawa Medical University, Kanazawa, Ishikawa, Japan
Results High FDG uptake correlated with negative E-cadherin expression (P = 0.043). SUVmax was higher in a negative E-cadherin expression lung adenocarcinoma than in a positive E-cadherin expression lung adenocarcinoma (P = 0.033). Patients with moderately poorly differentiated adenocarcinoma had frequent negative E-cadherin expression or high FDG uptake (P = 0.004, P = 0.0001, respectively). Patients with aggressive adenocarcinoma had frequent negative E-cadherin expression or high FDG uptake (P = 0.004, P = 0.001, respectively). Kaplan–Meier analysis revealed that negative E-cadherin expression or high FDG uptake were strongly correlated with shortened disease-free survival (P = 0.0153, P = 0.0001, respectively). Conclusion High FDG uptake on PET was associated with negative E-cadherin expression in patients with lung adenocarcinoma. Both high FDG uptake and negative E-cadherin expression were strongly correlated with poor differentiation, aggressiveness, and post-operative recurrence. These findings may cause the association between high FDG uptake and negative E-cadheri
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