High Levels of Il-19 in Patients with Chronic Inflammatory Demyelinating Polyneuropathy
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High Levels of Il-19 in Patients with Chronic Inflammatory Demyelinating Polyneuropathy Somayeh Sangsefidi 1 & Soudeh Ghafouri-Fard 2 & Alireza Komaki 3 & Mehrdokht Mazdeh 4 & Mohammad Taheri 5 Mohammad Mahdi Eftekharian 3
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Received: 3 April 2020 / Accepted: 19 May 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Immune-mediated neuropathies include some specific types such as acute and chronic inflammatory demyelinating polyneuropathy (AIDP and CIDP). Previous studies have demonstrated abnormal cellular or humoral immune responses in these conditions. Although aberrant regulation of several cytokines have been reported in AIDP and CIDP, the significance of interleukin 19 (IL-19) in these conditions have not been elucidated yet. In the current study, we assessed serum levels of IL19 in 12 CIDP patients (female/male ratio, 4/8), 9 AIDP patients (female/male ratio, 3/6), and 27 normal subjects (female/male ratio. 8/19) using commercial ELISA kits. Notably, we detected higher levels of this cytokine in CIDP patients (136.4 ± 8.57 ng/l) compared with both AIDP patients (93.89 ± 2.26 ng/l) and controls (83.78 ± 1.72 ng/l). However, the differences between AIDP patients and controls were not significant. The current study demonstrates the role of IL-19 in the pathogenesis of CIDP and potentiates this cytokine as a biomarker for this condition. Keywords Inflammatory demyelinating polyneuropathy . IL-19 . Guillain-Barre syndrome
Introduction Immune-mediated peripheral neuropathies are a group of potentially treatable diseases of peripheral nervous system in which aberrant immune responses have prominent roles (Chandra et al. 2018). This clinical entity includes GuillainBarre syndrome (GBS) and variants, chronic inflammatory demyelinating neuropathy (CIDP) and variants in addition to other less frequent conditions (Köller et al. 2005; Lehmann
* Mohammad Taheri [email protected] * Mohammad Mahdi Eftekharian [email protected] 1
Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
4
Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran
5
Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
et al. 2009). As the most frequent acute type of immunemediated peripheral neuropathy, GBS has a monophasic nature in most cases. This condition is classified into the following clinical entities: acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal polyneuropathy, and some other rarer conditions and is usually induced by infections, vaccines or immune-associated failure of bloodnerve barrier (BNB) (Chandra et al. 2018). Several studies have reported dysregulation of immune responses in these conditions (Nyati and Prasad 2014). Secretion of cytokines by infiltrati
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