Red Cell Distribution Width is Associated with 30-day Mortality in Patients with Spontaneous Intracerebral Hemorrhage
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ORIGINAL WORK
Red Cell Distribution Width is Associated with 30‑day Mortality in Patients with Spontaneous Intracerebral Hemorrhage João Pinho1* , Lénia Silva2, Miguel Quintas‑Neves3, Leandro Marques4, José Manuel Amorim3, Arno Reich1 and Carla Ferreira4 © 2020 The Author(s)
Abstract Background: Red cell distribution width (RDW) has been associated with mortality and outcome in a wide variety of non-neurological and neurological diseases, namely in myocardial infarction and acute ischemic stroke, and the rea‑ son for this is not completely understood. We aimed to investigate RDW as a potential prognostic marker in patients with intracerebral hemorrhage (ICH). Methods: This is a retrospective study of consecutive patients with acute non-traumatic ICH admitted to a single center during a 4-year period. We reviewed individual clinical records to collect demographic and baseline informa‑ tion, including RDW at admission, 3-month functional status, and incidence of death during follow-up. Baseline com‑ puted tomography imaging was reviewed to classify the location of ICH, and to measure ICH volume and perihema‑ tomal edema volume. Patients were divided according to quartile distribution of RDW (RDW-Q1-4). Results: The final study population consisted of 358 patients, median age 71 years (interquartile range [IQR] 60–80), 55% were male, and median Glasgow Coma Scale was 14 (IQR 10–15), with a mean follow-up of 17.6 months. Patients with higher RDW values were older (p = 0.003), more frequently presented with an active malignancy (p = 0.005), atrial fibrillation (p
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