Histamine and Its Receptors as a Module of the Biogenic Amine Diseasome
Biogenic amines play important roles in most important physiological processes, from cell proliferation and differentiation to nutrition, immune response, and neurobiology and reproduction. These effects are spread through a wide variety of cell-specific
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Histamine and Its Receptors as a Module of the Biogenic Amine Diseasome Rocío Rodríguez-López, María Morales, and Francisca Sánchez-Jiménez
Abstract Biogenic amines play important roles in most important physiological processes, from cell proliferation and differentiation to nutrition, immune response, and neurobiology and reproduction. These effects are spread through a wide variety of cellspecific receptors, cell-specific signaling, and metabolic pathways. However, the biochemical events underlying these effects conform very complex networks of interactions that are far from being completely understood in most cases. In addition, two or more biogenic amines can coexist in the same physiological scenarios keeping cross talk events with influence in their respective physiological functions. In this respect, histamine seems to be the most pleiotropic biogenic amine keeping biochemical and functional interactions with both growth-related polyamines and neurotransmitters in different cell models and tissues. As diseases are the consequence of a biochemical imbalance in one or more tissues, the physiological importance of these compounds and their multiple relationships must have a reflection in the human diseasome, the scope of which is not yet known. This fact impedes development of new solutions for diagnosis, prognosis, and treatment of the multiple diseases involving the action of biogenic amines. This work is a further effort of our group to integrate genetic, functional, and clinical information about biogenic amine-related diseases assisted by text mining and network theory-based tools with the aim of helping to advance in personalized biomedical strategies.
R. Rodríguez-López Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Campus Andalucía-Tech, Campus de Teatinos, Malaga 29071, Spain Instituto de Biomedicina IBIMA, Campus de Teatinos, Malaga 29071, Spain e-mail: [email protected]; [email protected] M. Morales Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Campus Andalucía-Tech, Campus de Teatinos, Malaga 29071, Spain e-mail: [email protected] F. Sánchez-Jiménez, Ph.D. (*) Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Campus Andalucía-Tech, Campus de Teatinos, Malaga 29071, Spain Unidad 741 CIBER de Enfermedades Raras, Campus de Teatinos, Malaga 29071, Spain Instituto de Biomedicina IBIMA, Campus de Teatinos, Malaga 29071, Spain © Springer International Publishing Switzerland 2016 P. Blandina, M.B. Passani (eds.), Histamine Receptors, The Receptors 28, DOI 10.1007/978-3-319-40308-3_7
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Keywords Histamine • G-protein-coupled receptors • Dopamine • Serotonin • Polyamines • Amine oxidases • Cancer • Inflammation • Neurotransmission • Rare diseases • Systems medicine
Abbreviations 5′-HT Ac ADHD DA DFMO GABA GO GWAS H1R H2R H3R H4R Hia HPO ODC OMIM PA PLP Put ROS Spd Spm
7.1
5′-Hydroxitriptamine or serotonin Acetyl moiety Attention-defi
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