Histamine Receptors as Drug Targets
This book illustrates the current state-of-the-art in histamine research, with a focus on the appropriate methodologies to investigate the pharmacological properties and the therapeutic exploitation of HRs and their ligands. In addition, the range of
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Ekaterini Tiligada Madeleine Ennis Editors
Histamine Receptors as Drug Targets
Methods and
in
Pharmacology
Toxicology
Series editor: Y. James Kang University of Louisville School of Medicine Prospect, Kentucky, USA
For further volumes: http://www.springer.com/series/7653
Histamine Receptors as Drug Targets Edited by
Ekaterini Tiligada Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Madeleine Ennis Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast, Northern Ireland, UK
Editors Ekaterini Tiligada Department of Pharmacology Medical School National and Kapodistrian University of Athens Athens, Greece
Madeleine Ennis Centre for Experimental Medicine School of Medicine Dentistry and Biomedical Sciences Queen’s University Belfast Belfast, Northern Ireland, UK
ISSN 1557-2153 ISSN 1940-6053 (electronic) Methods in Pharmacology and Toxicology ISBN 978-1-4939-6841-1 ISBN 978-1-4939-6843-5 (eBook) DOI 10.1007/978-1-4939-6843-5 Library of Congress Control Number: 2017931656 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Histamine [2-(4-imidazolyl) ethylamine] is a biogenic amine that is synthesized from the amino acid l-histidine through the catalytic activity of histidine decarboxylase (HDC, EC 4.1.1.22) and catabolized by two enzymes, namely diamine oxidase (DAO, EC 1.4.3.6) and histamine N-methyltransferase (HNMT, EC 2.1.1.8) [1, 2]. The history of histamine and antihistamines reflects numerous pioneering moments in the development of phar
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