HIV Interactions with Dendritic Cells Infection and Immunity
Given rapid research progress and advance of the techniques in studying HIV interactions with host cells and factors, there is a critical need for a book on HIV interactions with DCs. The proposed book will aim for a broad readership to facilitate HIV/AID
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A Adaptive immunity, 186–187. See also Innate and adaptive immunity Adenovirus-based vaccine vectors enhanced infection and activation, 277–278 susceptibility, 276–277 Adjuvant effects, 272–273 functions, 271 TLR ligands, 273–275 Antigen presentation, 204, 205 Antigen processing pathways, DCE antiviral immunity, 16 cross-presentation, 15 MHCI, 13, 15 MHCII, 14–15 pathways, 13, 14 Antiretroviral therapy (ART), 45, 94 Antiviral immune responses antigen presentation, DCs crosspresentation, 51 MHC class I, 50–51 MHC class II, 51 cytokine production and DCs, 55–56 HIV-1 infections (see Human immunodeficiency virus-1 (HIV-1) infections) human immune system DC subsets, 49–50 innate and adaptive, 46–48 T helper differentiation, 47, 49 PRRs (see Pattern recognition receptors (PRRs)) Attenuated virus infection circulating DCs impacts, 168–170 Nef expression, 167–168 Autophagy, 123, 211
C CD4+ T cells, 117–118 Cell-extrinsic innate interactions DC-SIGN, 188–189 epithelial cells, DCs, and HIV-1, 190–191 NK cells, DCs, and HIV-1, 191 TLR7 and TLR8, 188 TLR7 in pDCs, 189–190 Cell-intrinsic interactions antigen presentation and, 194 envelope-dependent sensing, 191–192 HIV-1 capsid by Simian TRIM5, 192–193 negative regulation by TREX1, 192 replicating virus and viral debris, 195 SAMHD1-restricted capsid-dependent innate sensing, 193–194 Cis-and trans-infection DC maturation effects, 114–115 mechanisms, 112–114 CLR domain family members (CLECs), 6 CLRs. See C-type lectin receptors (CLRs) Common DC progenitors (CDP), 74–75 Coxsackie-adenovirus receptor (CAR), 276 CpG motifs, 275 C-type lectin receptors (CLRs), 54–55 DC activation and maturation, 208–209 DC-SIGN, 6, 8, 206–207 HIV binding, 9 HIV-DC interactions, 207–208 HIV-1-gp120 interactions, 209 langerin, 9 mannose receptor, 8 pathogen binding and internalization, 206 structure, 6, 7 types, 206 Cytoplasmic PRRs, 10
L. Wu and O. Schwartz (eds.), HIV Interactions with Dendritic Cells: Infection and Immunity, Advances in Experimental Medicine and Biology 762, DOI 10.1007/978-1-4614-4433-6, © Springer Science+Business Media New York 2013
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290 Cytosine-guanosine dinucleotides (CpG), 75–76 Cytoskeleton-dependent macromolecular movement, 122–123
D DC-SIGN, 59, 61, 206–207 Dendritic cell and HIV-1 infections in cis and in trans-infection, 59, 60 cytokine production, 61 cytotoxic T cell activation, 62 DC-SIGN, 59, 61 latently infected reservoir establishment, 63 T helper cell activation, 62–63 Dendritic cell (DCs) and HIV-1 vaccines antigen delivery systems and adjuvants, 278 antigen-specific protective antibody responses, 264 functions, 266–267 future prospects, 279 rAd35 enhanced infection and activation, 277–278 susceptibility, 276–277 receptor specific antibodies CD40, 270 DEC-205, 269 HIV-1 Gag, 270–271 monoclonal, 269 TLRs and CLRs expression, 268 subset distribution, 265–266 vaccine adjuvants and activation effects, 272–273 functions, 271 TLR ligands, 273–275 VaxGen gp120 vaccine, 265 Dendritic cell-mediated HIV-1 trans-infection exosome mimicry, 144–145 GSLs chronic immune a
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