HIV Vaccines and Cure The Path Towards Finding an Effective Cure an
This book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In a
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Linqi Zhang · Sharon R. Lewin Editors
HIV Vaccines and Cure
The Path Towards Finding an Effective Cure and Vaccine
Advances in Experimental Medicine and Biology Volume 1075
Editorial Board IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy NIMA REZAEI, Tehran University of Medical Sciences Children’s Medical Center, Children’s Medical Center Hospital, Tehran, Iran
More information about this series at http://www.springer.com/series/5584
Linqi Zhang • Sharon R. Lewin Editors
HIV Vaccines and Cure The Path Towards Finding an Effective Cure and Vaccine
Editors Linqi Zhang Comprehensive AIDS Research Center, School of Medicine, Tsinghua University Beijing, China
Sharon R. Lewin The Peter Doherty Institute for Infection and Immunity University of Melbourne and Royal Melbourne Hospital Melbourne, VIC, Australia
ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-981-13-0483-5 ISBN 978-981-13-0484-2 (eBook) https://doi.org/10.1007/978-981-13-0484-2 Library of Congress Control Number: 2018948148 © Springer Nature Singapore Pte Ltd. 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Preface
The success of antiretroviral therapy (ART) in the management of HIV infection has been one of the most spectacular successes in medicine in the last century. ART led to the transformation of HIV from a universal death sentence to a chronic manageable disease. In every part of t
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