HLA-B*35 as a new marker for susceptibility to human T-cell lymphotropic virus type 1 (HTLV-1) Associated Myelopathy/Tro
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Retrovirology Open Access
RESEARCH
HLA‑B*35 as a new marker for susceptibility to human T‑cell lymphotropic virus type 1 (HTLV‑1) Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in patients living in Argentina Paula Benencio1, Sindy A. Fraile Gonzalez1, Nicolás Ducasa1, Kimberly Page2,3, Carolina A. Berini1*† and Mirna M. Biglione1†
Abstract Background: Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of HTLV associated myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) and Adult T cell leukemia/lymphoma (ATLL), in around 2–5% of the infected individuals. Host genetic background might play a role in disease progression. Several previous studies across many countries report HLA haplotype to be one such factor. Here, we sequenced HLA-A, -B and -C of 66 individuals by Sequence-Based Typing (SBT), and compared the frequency of different alleles among ATLL patients, HAM/TSP patients, asymptomatic carriers and non-infected individuals living in Argentina. Results: The frequency of HLA-A, -B and -C alleles largely matched that of the general population in Argentina. We identified HLA-A*02, HLA-B*35 and HLA-C*07 as associated to protection from ATLL (p = 0.031), susceptibility to HAM/ TSP (p
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