Honey and curcumin loaded multilayered polyvinylalcohol/cellulose acetate electrospun nanofibrous mat for wound healing
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Honey and curcumin loaded multilayered polyvinylalcohol/cellulose acetate electrospun nanofibrous mat for wound healing Mrunalini K. Gaydhane1,a)
, Jaya S. Kanuganti1, Chandra S. Sharma1
1
Creative and Advanced Research Based on Nanomaterials (CARBON) Laboratory, Department of Chemical Engineering, Indian Institute of Technology Hyderabad, Sangareddy, Telangana 502285, India a) Address all correspondence to this author. e-mail: [email protected] Received: 15 November 2019; accepted: 13 February 2020
Bioactive dressings which can treat any kind of chronic or acute wounds and can fully replace the conventional gauzes and superabsorbent dressings have proven to be a future market of wound care products in recent times. These dressings are multifunctional, which can effectively combat the wound infection, remove the exudate, promote angiogenesis, and protect the wound from external trauma. Proper selection of bioactive and polymer defines its efficiency. Current research unveils the therapeutic efficacy of curcumin–honey-loaded multilayered polyvinyl alcohol/cellulose acetate electrospun nanofibrous mats as an interactive bioactive wound dressing material. Scanning electron microscopy and Fourier transform infrared spectroscopy analysis infers uniform encapsulation and chemical compatibility of herbal actives and polymer, inside the nanofibrous layers. The as-spun mat shows potential resistance towards Escherichia coli and ∼90% antioxidant activity against diphenyl-picrylhydrazyl (DPPH)–free radical. Additionally, water absorbency, water vapor transmission rate, and wettability analysis show quick and excellent absorption with controlled transmission of wound exudate.
Introduction Every year, across the globe, nearly 300 millions of people are treated for acute wounds, whereas 50 million people endure chronic wounds [1, 2, 3, 4]. Wound dressing plays a vital role in hastening wound-healing process. While healing, any wound passes through hemostasis, inflammatory, cell proliferative, and tissue remodeling stages [4, 5, 6]. To accelerate healing, dressing should meet the following criteria: (i) control or prevent the microbial infection in wound and its surrounding, (ii) absorb the exudate, (iii) maintain desired moisture for optimum healing and should be permeable to air and moisture without desiccating the wound, and (iv) should be comfortable and protect the wound from any kind of mechanical trauma [3, 7]. In recent times, emergence of antibiotic resistance has imposed additional complications and delay in treating a majority of infections. The reason for antibiotic resistance can be attributed to two factors viz. inappropriate use of antimicrobials and the build-up of resistance through cell to cell talk in polymicrobial biofilms [8, 9]. The biofilm structure itself restricts the penetration of antimicrobials to reach the
ª Materials Research Society 2020
innermost bacteria. There are three distinguished techniques to deal with the eradication of bacteria in biofilms. It involves use of antimicrobials, or contac
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