Hormones, Intrauterine Health and Programming
The environment of the fetus in the womb is emerging as a key determinant not only of its immediate status but also of the offspring’s long-term well-being. This largely started with reports of striking epidemiological associations between lower, but stil
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J.R. Seckl Y. Christen (Eds.)
Hormones, Intrauterine Health and Programming
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Research and Perspectives in Endocrine Interactions
For further volumes: http://www.springer.com/series/5241
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Jonathan R Seckl • Yves Christen Editors
Hormones, Intrauterine Health and Programming
Editors Jonathan R Seckl Endocrinology Unit University of Edinburgh Queen’s Medical Research Inst Edinburgh United Kingdom
Yves Christen Fondation IPSEN Boulogne-Billancourt Cedex France
ISSN 1861-2253 ISSN 1863-0685 (electronic) ISBN 978-3-319-02590-2 ISBN 978-3-319-02591-9 (eBook) DOI 10.1007/978-3-319-02591-9 Springer Cham Heidelberg New York Dordrecht London Library of Congress Control Number: 2014940726 © Springer International Publishing Switzerland 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Foreword
In the last two decades a plethora of studies have extended the classical genes adult environment paradigm of disease aetiology to include early life development (genes development environment). An early and powerful example comes from the epidemiological studies of Barker and colleagues linking low birth weight (a rather blunt marker of “something went wrong in utero”) with a substantially increased risk of cardio-metabolic and neuropsychiatric disorders in
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