Human Herpesviruses

This book introduces and reviews several topics for each human herpesvirus. One of the most important features of the book is that it covers aspects of both basic research and clinical medicine. Herpesviridae, a family of double-strand DNA viruses, has un

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Yasushi Kawaguchi · Yasuko Mori  Hiroshi Kimura Editors

Human Herpesviruses

Advances in Experimental Medicine and Biology Volume 1045

Editorial Board IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S.Kline Institute for Psychiatric Research, Orangeburg,  NY, USA JOHN D. LAMBRIS, University of Pennsylvania Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy NIMA REZAEI, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

More information about this series at http://www.springer.com/series/5584

Yasushi Kawaguchi  •  Yasuko Mori Hiroshi Kimura Editors

Human Herpesviruses

Editors Yasushi Kawaguchi Division of Molecular Virology Department of Microbiology and Immunology The Institute of Medical Science The University of Tokyo Minato-ku, Tokyo, Japan Department of Infectious Disease Control, International Research Center for Infectious Diseases The Institute of Medical Science The University of Tokyo Minato-ku, Tokyo, Japan

Yasuko Mori Division of Clinical Virology Kobe University Graduate School of Medicine Kobe, Hyogo, Japan Hiroshi Kimura Department of Virology Nagoya University Graduation School of Medicine Nagoya, Aichi, Japan

Research Center for Asian Infectious Diseases The Institute of Medical Science The University of Tokyo Minato-ku, Tokyo, Japan

ISSN 0065-2598     ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-981-10-7229-1    ISBN 978-981-10-7230-7 (eBook) https://doi.org/10.1007/978-981-10-7230-7 Library of Congress Control Number: 2018941559 © Springer Nature Singapore Pte Ltd. 2018 Chapter 22: This is a U.S. government work and its text is not subject to copyright protection in the United States; however, its text may be subject to foreign copyright protection 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed o