• PDF / 317,575 Bytes
• 11 Pages / 612.28 x 790.87 pts Page_size
• 63 Downloads / 230 Views

DOWNLOAD

REPORT

REVIEW ARTICLE

ª 2012 Adis Data Information BV. All rights reserved.

Hybrid Compounds From Simple Combinations to Nanomachines Andreas Mu¨ller-Schiffmann,1 Heinrich Sticht2 and Carsten Korth1 1 Department of Neuropathology, Heinrich Heine University Du¨sseldorf, Du¨sseldorf, Germany 2 Institute for Biochemistry, University of Erlangen-Nu¨rnberg, Erlangen, Germany

Contents Abstract. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 1. Result of an Evolutionary Process: Natural Hybrid Compounds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 1.1 Multifunctional Proteins: Botulinum Toxin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.2 Small-Molecule Multifunctional Compounds: Bleomycin. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2. Combining Compounds that Target the Same Pathway Simultaneously . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3. Hybrid Compounds Acting on the Same Molecular Target . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

23 23 23 25

3.1 Compounds with Several Functional Moieties. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 3.2 Compounds with a Targeting Moiety and a Functional Moiety . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 3.2.1 Targeting to the Functional Unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 3.2.2 Targeting a Metabolizing Pathway . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 4. Towards Biology-Inspired Multifunctional Nanomachines . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28 4.1 Modular Nanotransporters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28 5. Concluding Remarks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30

Abstract

The combination of two different and independently acting compounds into one covalently linked hybrid compound can convey synergy from the effects of both independently acting moieties to the new composi

Recommend Documents

Synthesis of PbTiO 3 /organic hybrid from metalorganic compounds

240 40 456KB

The Chemical Bonding of Organic-Inorganic in Hybrid Compounds

224 29 129KB

Synthesis of magnetic particle/organic hybrid from metalorganic compounds

185 15 332KB

Two Synthetic Routes to The Formation of Tungsten Oxide Hybrid Compounds

178 4 833KB

Synthesis and characterization of advanced hybrid titanium compounds/F-MWCNTs nanocomposites and their antibacterial act

212 86 6MB

Titanium Oxo-Clusters: Vesatile Nano-Objects for the Design of Hybrid Compounds

151 68 493KB

Synthesis and Anticancer Activity of New Pyridine-Thiophene and Pyridine-Furan Hybrid Compounds, Their Sugar Hydrazone,

199 66 686KB

Organolead Compounds

159 95 28MB

Octanuclear Compounds

245 107 24MB

Organic Compounds

187 29 19MB

Polynuclear Compounds

202 50 24MB

Steroidal compounds

177 67 32KB